Assay Detail
Functional
CHEMBL2078155
Review assay metadata, readout intent, target linkage, and publication context from the same page.
TP_TRANSPORTER: inhibition of PAH uptake in Xenopus laevis oocytes
8
Total Activities
8
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Xenopus laevis |
| Cell Type | Oocyte |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Solute carrier family 22 member 6 (CHEMBL1777665) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Interaction and transport of thiazide diuretics, loop diuretics, and acetazolamide via rat renal organic anion transporter rOAT1.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Activity | 4 | - | - |
| Ki | 4 | 5.14 | 5.26 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1072 | BUMETANIDE | 4.0 | 1 | 5.26 |
| CHEMBL35 | FUROSEMIDE | 4.0 | 1 | 5.02 |
| CHEMBL19 | METHAZOLAMIDE | 4.0 | 1 | - |
| CHEMBL18 | ETHOXZOLAMIDE | 4.0 | 1 | - |
| CHEMBL61593 | CYCLOTHIAZIDE | 4.0 | 1 | - |
| CHEMBL842 | CHLOROTHIAZIDE | 4.0 | 1 | - |
| CHEMBL20 | ACETAZOLAMIDE | 4.0 | 1 | - |
| CHEMBL435 | HYDROCHLOROTHIAZIDE | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1072 | BUMETANIDE | Ki | = | 5500.0 | nM | 5.26 |
| CHEMBL35 | FUROSEMIDE | Ki | = | 9500.0 | nM | 5.02 |
| CHEMBL19 | METHAZOLAMIDE | Activity | - | — | - | |
| CHEMBL18 | ETHOXZOLAMIDE | Activity | - | — | - | |
| CHEMBL61593 | CYCLOTHIAZIDE | Activity | - | — | - | |
| CHEMBL842 | CHLOROTHIAZIDE | Activity | - | — | - | |
| CHEMBL20 | ACETAZOLAMIDE | Ki | = | 1100000.0 | nM | - |
| CHEMBL435 | HYDROCHLOROTHIAZIDE | Ki | = | 150000.0 | nM | - |