Assay Detail
Functional
CHEMBL2078385
Review assay metadata, readout intent, target linkage, and publication context from the same page.
TP_TRANSPORTER: cell accumulation in MCF7/MRP1-M24 cells
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Cell Type | MCF7/MRP1-M24 |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Multidrug resistance-associated protein 1 (CHEMBL3004) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Multidrug resistance protein 1 (MRP1, ABCC1) mediates resistance to mitoxantrone via glutathione-dependent drug efflux.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 1 | 8.82 | 8.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL58 | MITOXANTRONE | 4.0 | 1 | 8.82 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL58 | MITOXANTRONE | IC50 | = | 1.5 | nM | 8.82 |