Assay Detail
Functional
CHEMBL2078495
Review assay metadata, readout intent, target linkage, and publication context from the same page.
TP_TRANSPORTER: inhibition of TEA uptake (basolateral to cell) in OCT1-expressing MDCK cells
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Cell Type | MDCK |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Solute carrier family 22 member 1 (CHEMBL2073670) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Functional characteristics and membrane localization of rat multispecific organic cation transporters, OCT1 and OCT2, mediating tubular secretion of cationic drugs.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 7 | 4.94 | 6.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL311617 | — | — | 1 | 6.10 |
| CHEMBL30 | CIMETIDINE | 4.0 | 1 | 5.24 |
| CHEMBL1294 | QUINIDINE | 4.0 | 1 | 4.84 |
| CHEMBL9324 | TETRYLAMMONIUM | 2.0 | 1 | 4.33 |
| CHEMBL3 | NICOTINE | 4.0 | 1 | 4.19 |
| CHEMBL11978 | NICOTINYL METHYLAMIDE | -1.0 | 1 | - |
| CHEMBL821 | GUANIDINE | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL311617 | — | Ki | = | 800.0 | nM | 6.10 |
| CHEMBL30 | CIMETIDINE | Ki | = | 5700.0 | nM | 5.24 |
| CHEMBL1294 | QUINIDINE | Ki | = | 14600.0 | nM | 4.84 |
| CHEMBL9324 | TETRYLAMMONIUM | Ki | = | 46600.0 | nM | 4.33 |
| CHEMBL3 | NICOTINE | Ki | = | 64300.0 | nM | 4.19 |
| CHEMBL11978 | NICOTINYL METHYLAMIDE | Ki | = | 669200.0 | nM | - |
| CHEMBL821 | GUANIDINE | Ki | = | 724200.0 | nM | - |