Assay Detail
Binding
CHEMBL2089751
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human recombinant PTP1B using p-nitrophenyl phosphate as substrate assessed as p-nitrophenol release after 30 mins
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Tyrosine-protein phosphatase non-receptor type 1 (CHEMBL335) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Rhododendric acid A, a new ursane-type PTP1B inhibitor from the endangered plant Rhododendron brachycarpum G. Don.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 5.08 | 5.51 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL169 | URSOLIC ACID | 2.0 | 1 | 5.51 |
| CHEMBL426373 | — | — | 1 | 5.40 |
| CHEMBL2086414 | RHODODENDRIC ACID A | — | 1 | 5.20 |
| CHEMBL391533 | COROSOLIC ACID | — | 1 | 5.16 |
| CHEMBL523622 | — | — | 1 | 5.13 |
| CHEMBL2088611 | — | — | 1 | 4.76 |
| CHEMBL2088612 | ACTINIDIC ACID | — | 1 | 4.75 |
| CHEMBL1271052 | ROTUNDIC ACID | — | 1 | 4.70 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL169 | URSOLIC ACID | IC50 | = | 3100.0 | nM | 5.51 |
| CHEMBL426373 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL2086414 | RHODODENDRIC ACID A | IC50 | = | 6300.0 | nM | 5.20 |
| CHEMBL391533 | COROSOLIC ACID | IC50 | = | 7000.0 | nM | 5.16 |
| CHEMBL523622 | — | IC50 | = | 7400.0 | nM | 5.13 |
| CHEMBL2088611 | — | IC50 | = | 17400.0 | nM | 4.76 |
| CHEMBL2088612 | ACTINIDIC ACID | IC50 | = | 18000.0 | nM | 4.75 |
| CHEMBL1271052 | ROTUNDIC ACID | IC50 | = | 20100.0 | nM | 4.70 |