Assay Detail
Functional
CHEMBL2089834
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Antiviral activity against HIV1 in human TZM-bl cells assessed as viral infectivity by luciferase assay
22
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human immunodeficiency virus 1 |
| Cell Type | TZM-bl |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Target
Human immunodeficiency virus 1 (CHEMBL378) ↗| Type | ORGANISM |
| Organism | Human immunodeficiency virus 1 |
Publication
Anti-HIV activity of semisynthetic derivatives of andrographolide and computational study of HIV-1 gp120 protein binding.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 22 | 5.71 | 7.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL137752 | — | — | 2 | 7.00 |
| CHEMBL2088490 | — | — | 2 | 6.29 |
| CHEMBL186141 | ANDROGRAPHOLIDE | 3.0 | 2 | 6.23 |
| CHEMBL2088492 | — | — | 2 | 6.08 |
| CHEMBL2088489 | — | — | 2 | 5.96 |
| CHEMBL2088488 | — | — | 2 | 5.68 |
| CHEMBL2088491 | — | — | 2 | 5.68 |
| CHEMBL2088486 | — | — | 2 | 5.56 |
| CHEMBL2088487 | — | — | 2 | 5.22 |
| CHEMBL377422 | — | — | 2 | 5.00 |
| CHEMBL2088493 | — | — | 2 | 4.07 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL137752 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL137752 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL2088490 | — | IC50 | = | 512.86 | nM | 6.29 |
| CHEMBL2088490 | — | IC50 | = | 510.0 | nM | 6.29 |
| CHEMBL186141 | ANDROGRAPHOLIDE | IC50 | = | 588.84 | nM | 6.23 |
| CHEMBL186141 | ANDROGRAPHOLIDE | IC50 | = | 590.0 | nM | 6.23 |
| CHEMBL2088492 | — | IC50 | = | 830.0 | nM | 6.08 |
| CHEMBL2088492 | — | IC50 | = | 831.76 | nM | 6.08 |
| CHEMBL2088489 | — | IC50 | = | 1090.0 | nM | 5.96 |
| CHEMBL2088489 | — | IC50 | = | 1096.48 | nM | 5.96 |
| CHEMBL2088488 | — | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL2088491 | — | IC50 | = | 2089.3 | nM | 5.68 |
| CHEMBL2088488 | — | IC50 | = | 2089.3 | nM | 5.68 |
| CHEMBL2088491 | — | IC50 | = | 2080.0 | nM | 5.68 |
| CHEMBL2088486 | — | IC50 | = | 2754.23 | nM | 5.56 |
| CHEMBL2088486 | — | IC50 | = | 2750.0 | nM | 5.56 |
| CHEMBL2088487 | — | IC50 | = | 6025.6 | nM | 5.22 |
| CHEMBL2088487 | — | IC50 | = | 6090.0 | nM | 5.21 |
| CHEMBL377422 | — | IC50 | = | 9940.0 | nM | 5.00 |
| CHEMBL377422 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL2088493 | — | IC50 | = | 84240.0 | nM | 4.07 |
| CHEMBL2088493 | — | IC50 | = | 85113.8 | nM | 4.07 |