Assay Detail
Binding
CHEMBL2089873
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Inhibition of JNK1-mediated ATF2 phosphorylation after 1 hr by ELISA
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Diaminopyridine-based potent and selective mps1 kinase inhibitors binding to an unusual flipped-Peptide conformation.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 6.79 | 8.33 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL424872 | — | — | 1 | 8.33 |
| CHEMBL2089254 | — | — | 1 | 6.72 |
| CHEMBL2089255 | — | — | 1 | 6.64 |
| CHEMBL210861 | — | — | 1 | 6.58 |
| CHEMBL211195 | — | — | 1 | 6.46 |
| CHEMBL2089253 | — | — | 1 | 5.99 |
| CHEMBL2089252 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL424872 | — | IC50 | = | 4.7 | nM | 8.33 |
| CHEMBL2089254 | — | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL2089255 | — | IC50 | = | 231.0 | nM | 6.64 |
| CHEMBL210861 | — | IC50 | = | 260.0 | nM | 6.58 |
| CHEMBL211195 | — | IC50 | = | 350.0 | nM | 6.46 |
| CHEMBL2089253 | — | IC50 | = | 1035.0 | nM | 5.99 |
| CHEMBL2089252 | — | IC50 | > | 100000.0 | nM | - |