Assay Detail
Binding
CHEMBL2090278
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of EGFR-mediated intracellular tyrosine phosphorylation in EGF-stimulated human A431 cells after 2.5 hrs by SDS-PAGE analysis
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | A-431 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis and biological evaluation of crown ether fused quinazoline analogues as potent EGFR inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 7.31 | 7.35 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2087360 | — | — | 1 | 7.35 |
| CHEMBL2087361 | ICOTINIB | 3.0 | 1 | 7.35 |
| CHEMBL2087355 | — | — | 1 | 7.30 |
| CHEMBL2087356 | — | — | 1 | 7.30 |
| CHEMBL2087358 | — | — | 1 | 7.26 |
| CHEMBL1198361 | — | — | 1 | - |
| CHEMBL2087352 | — | — | 1 | - |
| CHEMBL2087353 | — | — | 1 | - |
| CHEMBL2087354 | — | — | 1 | - |
| CHEMBL2087357 | — | — | 1 | - |
| CHEMBL2087359 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2087360 | — | IC50 | = | 45.0 | nM | 7.35 |
| CHEMBL2087361 | ICOTINIB | IC50 | = | 45.0 | nM | 7.35 |
| CHEMBL2087355 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL2087356 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL2087358 | — | IC50 | = | 55.0 | nM | 7.26 |
| CHEMBL1198361 | — | IC50 | - | — | - | |
| CHEMBL2087352 | — | IC50 | - | — | - | |
| CHEMBL2087353 | — | IC50 | - | — | - | |
| CHEMBL2087354 | — | IC50 | - | — | - | |
| CHEMBL2087357 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL2087359 | — | IC50 | > | 1000.0 | nM | - |