Assay Detail
Functional
CHEMBL2090300
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Antiplatelet activity against rabbit platelets assessed as inhibition of thrombin-induced platelet aggregation
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Oryctolagus cuniculus |
| Cell Type | Platelet |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis and antithrombotic evaluation of novel dabigatran prodrugs containing a cleavable moiety with anti-platelet activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 6.98 | 8.50 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2087701 | — | — | 1 | 8.50 |
| CHEMBL2087702 | — | — | 1 | 7.42 |
| CHEMBL2087705 | — | — | 1 | 7.14 |
| CHEMBL2087703 | — | — | 1 | 6.66 |
| CHEMBL2087704 | — | — | 1 | 6.54 |
| CHEMBL2087707 | — | — | 1 | 6.54 |
| CHEMBL2087706 | — | — | 1 | 6.53 |
| CHEMBL539697 | DABIGATRAN ETEXILATE | 4.0 | 1 | 6.49 |
| CHEMBL63331 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2087701 | — | IC50 | = | 3.13 | nM | 8.50 |
| CHEMBL2087702 | — | IC50 | = | 38.1 | nM | 7.42 |
| CHEMBL2087705 | — | IC50 | = | 72.8 | nM | 7.14 |
| CHEMBL2087703 | — | IC50 | = | 218.0 | nM | 6.66 |
| CHEMBL2087704 | — | IC50 | = | 292.0 | nM | 6.54 |
| CHEMBL2087707 | — | IC50 | = | 287.0 | nM | 6.54 |
| CHEMBL2087706 | — | IC50 | = | 295.0 | nM | 6.53 |
| CHEMBL539697 | DABIGATRAN ETEXILATE | IC50 | = | 326.0 | nM | 6.49 |
| CHEMBL63331 | — | IC50 | = | 8410000.0 | nM | - |