Assay Detail
Binding
CHEMBL2090336
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Inhibition of mouse p38apha assessed as reduction in GST-ATF2 substrate phosphorylation by SPA assay
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mus musculus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis and biological activity of pyridopyridazin-6-one p38α MAP kinase inhibitors. Part 2.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 20 | 8.35 | 9.48 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2088591 | — | — | 1 | 9.48 |
| CHEMBL2088578 | — | — | 1 | 9.24 |
| CHEMBL2088588 | — | — | 1 | 9.24 |
| CHEMBL2088582 | — | — | 1 | 8.89 |
| CHEMBL2088590 | — | — | 1 | 8.80 |
| CHEMBL2088589 | — | — | 1 | 8.80 |
| CHEMBL2088583 | — | — | 1 | 8.64 |
| CHEMBL2088575 | — | — | 1 | 8.64 |
| CHEMBL2088579 | — | — | 1 | 8.48 |
| CHEMBL2088586 | — | — | 1 | 8.33 |
| CHEMBL2088576 | — | — | 1 | 8.24 |
| CHEMBL1098524 | — | — | 1 | 8.15 |
| CHEMBL2088587 | — | — | 1 | 8.06 |
| CHEMBL2088580 | — | — | 1 | 8.05 |
| CHEMBL2088577 | — | — | 1 | 8.00 |
| CHEMBL1096192 | — | — | 1 | 7.89 |
| CHEMBL1098546 | — | — | 1 | 7.85 |
| CHEMBL2088585 | — | — | 1 | 7.77 |
| CHEMBL2088584 | — | — | 1 | 7.50 |
| CHEMBL2088581 | — | — | 1 | 7.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2088591 | — | IC50 | = | 0.33 | nM | 9.48 |
| CHEMBL2088578 | — | IC50 | = | 0.58 | nM | 9.24 |
| CHEMBL2088588 | — | IC50 | = | 0.58 | nM | 9.24 |
| CHEMBL2088582 | — | IC50 | = | 1.3 | nM | 8.89 |
| CHEMBL2088590 | — | IC50 | = | 1.6 | nM | 8.80 |
| CHEMBL2088589 | — | IC50 | = | 1.6 | nM | 8.80 |
| CHEMBL2088583 | — | IC50 | = | 2.3 | nM | 8.64 |
| CHEMBL2088575 | — | IC50 | = | 2.3 | nM | 8.64 |
| CHEMBL2088579 | — | IC50 | = | 3.3 | nM | 8.48 |
| CHEMBL2088586 | — | IC50 | = | 4.7 | nM | 8.33 |
| CHEMBL2088576 | — | IC50 | = | 5.8 | nM | 8.24 |
| CHEMBL1098524 | — | IC50 | = | 7.1 | nM | 8.15 |
| CHEMBL2088587 | — | IC50 | = | 8.8 | nM | 8.06 |
| CHEMBL2088580 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL2088577 | — | IC50 | = | 9.9 | nM | 8.00 |
| CHEMBL1096192 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL1098546 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL2088585 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL2088584 | — | IC50 | = | 32.0 | nM | 7.50 |
| CHEMBL2088581 | — | IC50 | = | 99.0 | nM | 7.00 |