Assay Detail
Binding
CHEMBL2090337
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Inhibition of mouse p38beta assessed as reduction in GST-ATF2 substrate phosphorylation by SPA assay
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mus musculus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis and biological activity of pyridopyridazin-6-one p38α MAP kinase inhibitors. Part 2.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 20 | 7.19 | 8.11 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2088578 | — | — | 1 | 8.11 |
| CHEMBL2088591 | — | — | 1 | 8.07 |
| CHEMBL1098524 | — | — | 1 | 8.04 |
| CHEMBL2088588 | — | — | 1 | 8.03 |
| CHEMBL1096192 | — | — | 1 | 7.80 |
| CHEMBL1098546 | — | — | 1 | 7.77 |
| CHEMBL2088582 | — | — | 1 | 7.57 |
| CHEMBL2088575 | — | — | 1 | 7.44 |
| CHEMBL2088579 | — | — | 1 | 7.27 |
| CHEMBL2088590 | — | — | 1 | 7.19 |
| CHEMBL2088583 | — | — | 1 | 7.18 |
| CHEMBL2088586 | — | — | 1 | 7.07 |
| CHEMBL2088589 | — | — | 1 | 6.96 |
| CHEMBL2088587 | — | — | 1 | 6.85 |
| CHEMBL2088576 | — | — | 1 | 6.75 |
| CHEMBL2088580 | — | — | 1 | 6.70 |
| CHEMBL2088577 | — | — | 1 | 6.64 |
| CHEMBL2088585 | — | — | 1 | 6.52 |
| CHEMBL2088584 | — | — | 1 | 6.40 |
| CHEMBL2088581 | — | — | 1 | 5.52 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2088578 | — | IC50 | = | 7.7 | nM | 8.11 |
| CHEMBL2088591 | — | IC50 | = | 8.5 | nM | 8.07 |
| CHEMBL1098524 | — | IC50 | = | 9.2 | nM | 8.04 |
| CHEMBL2088588 | — | IC50 | = | 9.3 | nM | 8.03 |
| CHEMBL1096192 | — | IC50 | = | 15.8 | nM | 7.80 |
| CHEMBL1098546 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL2088582 | — | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL2088575 | — | IC50 | = | 36.0 | nM | 7.44 |
| CHEMBL2088579 | — | IC50 | = | 53.5 | nM | 7.27 |
| CHEMBL2088590 | — | IC50 | = | 64.0 | nM | 7.19 |
| CHEMBL2088583 | — | IC50 | = | 66.0 | nM | 7.18 |
| CHEMBL2088586 | — | IC50 | = | 86.0 | nM | 7.07 |
| CHEMBL2088589 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL2088587 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL2088576 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL2088580 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL2088577 | — | IC50 | = | 230.0 | nM | 6.64 |
| CHEMBL2088585 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL2088584 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL2088581 | — | IC50 | = | 3000.0 | nM | 5.52 |