Assay Detail
Functional
CHEMBL2090618
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Cytotoxicity against rat C6 cells incubated for 48 hrs by MTT assay
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Cell Type | C6 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Selective cytotoxicity and apoptosis induction in glioma cell lines by 5-oxygenated-6,7-methylenedioxycoumarins from Pterocaulon species.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 4.29 | 4.47 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL810 | TEMOZOLOMIDE | 4.0 | 1 | 4.47 |
| CHEMBL596222 | — | — | 1 | 4.46 |
| CHEMBL611815 | — | — | 1 | 4.12 |
| CHEMBL595800 | — | — | 1 | 4.11 |
| CHEMBL6466 | COUMARIN | 4.0 | 1 | - |
| CHEMBL51628 | UMBELLIFERONE | — | 1 | - |
| CHEMBL244743 | ESCULETIN | — | 1 | - |
| CHEMBL482581 | ESCULIN | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL810 | TEMOZOLOMIDE | IC50 | = | 34000.0 | nM | 4.47 |
| CHEMBL596222 | — | IC50 | = | 34600.0 | nM | 4.46 |
| CHEMBL611815 | — | IC50 | = | 76400.0 | nM | 4.12 |
| CHEMBL595800 | — | IC50 | = | 77500.0 | nM | 4.11 |
| CHEMBL6466 | COUMARIN | IC50 | - | — | - | |
| CHEMBL51628 | UMBELLIFERONE | IC50 | - | — | - | |
| CHEMBL244743 | ESCULETIN | IC50 | - | — | - | |
| CHEMBL482581 | ESCULIN | IC50 | - | — | - |