Assay Detail
Binding
CHEMBL2090690
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human recombinant His6-tagged DDAH1 expressed in Escherichia coli BL21(DE3) using Nomega,Nomega-dimethyl-L-arginine as substrate after 80 mins by colorimetric ureido derivitization assay
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
N(G),N(G)-dimethylarginine dimethylaminohydrolase 1 (CHEMBL6036) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Discovery of structurally-diverse inhibitor scaffolds by high-throughput screening of a fragment library with dimethylarginine dimethylaminohydrolase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 2.71 | 2.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL351569 | — | — | 1 | 2.85 |
| CHEMBL2087646 | — | — | 1 | 2.57 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL351569 | — | IC50 | = | 1400000.0 | nM | 2.85 |
| CHEMBL2087646 | — | IC50 | = | 2700000.0 | nM | 2.57 |