Assay Detail
Binding
CHEMBL2090696
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Inhibition of Trypanosoma brucei CatB
22
Total Activities
22
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Trypanosoma brucei |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Cathepsin B-like cysteine protease (CHEMBL5832) ↗| Type | SINGLE PROTEIN |
| Organism | Trypanosoma brucei |
Publication
Antitrypanosomal and cysteine protease inhibitory activities of alkyldiamine cryptolepine derivatives.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 22 | 4.25 | 4.58 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1290380 | — | — | 1 | 4.58 |
| CHEMBL1290489 | — | — | 1 | 4.58 |
| CHEMBL253508 | — | — | 1 | 4.51 |
| CHEMBL1290488 | — | — | 1 | 4.50 |
| CHEMBL1289050 | — | — | 1 | 4.37 |
| CHEMBL404321 | — | — | 1 | 4.37 |
| CHEMBL1289827 | — | — | 1 | 4.26 |
| CHEMBL1289049 | — | — | 1 | 4.23 |
| CHEMBL1290717 | — | — | 1 | 4.23 |
| CHEMBL1290599 | — | — | 1 | 4.23 |
| CHEMBL404523 | — | — | 1 | 4.22 |
| CHEMBL404522 | — | — | 1 | 4.21 |
| CHEMBL253716 | — | — | 1 | 4.21 |
| CHEMBL92129 | CRYPTOLEPINE HYDROCHLORIDE | — | 1 | 4.19 |
| CHEMBL1290718 | — | — | 1 | 4.19 |
| CHEMBL1289828 | — | — | 1 | 4.12 |
| CHEMBL439424 | — | — | 1 | 4.04 |
| CHEMBL252504 | — | — | 1 | 4.02 |
| CHEMBL253715 | — | — | 1 | 4.01 |
| CHEMBL1290598 | — | — | 1 | 4.00 |
| CHEMBL253717 | — | — | 1 | - |
| CHEMBL267856 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1290380 | — | IC50 | = | 26000.0 | nM | 4.58 |
| CHEMBL1290489 | — | IC50 | = | 26000.0 | nM | 4.58 |
| CHEMBL253508 | — | IC50 | = | 31000.0 | nM | 4.51 |
| CHEMBL1290488 | — | IC50 | = | 32000.0 | nM | 4.50 |
| CHEMBL1289050 | — | IC50 | = | 43000.0 | nM | 4.37 |
| CHEMBL404321 | — | IC50 | = | 43000.0 | nM | 4.37 |
| CHEMBL1289827 | — | IC50 | = | 55000.0 | nM | 4.26 |
| CHEMBL1289049 | — | IC50 | = | 59000.0 | nM | 4.23 |
| CHEMBL1290717 | — | IC50 | = | 59000.0 | nM | 4.23 |
| CHEMBL1290599 | — | IC50 | = | 59000.0 | nM | 4.23 |
| CHEMBL404523 | — | IC50 | = | 60000.0 | nM | 4.22 |
| CHEMBL404522 | — | IC50 | = | 62000.0 | nM | 4.21 |
| CHEMBL253716 | — | IC50 | = | 62000.0 | nM | 4.21 |
| CHEMBL92129 | CRYPTOLEPINE HYDROCHLORIDE | IC50 | = | 64000.0 | nM | 4.19 |
| CHEMBL1290718 | — | IC50 | = | 64000.0 | nM | 4.19 |
| CHEMBL1289828 | — | IC50 | = | 76000.0 | nM | 4.12 |
| CHEMBL439424 | — | IC50 | = | 91000.0 | nM | 4.04 |
| CHEMBL252504 | — | IC50 | = | 95000.0 | nM | 4.02 |
| CHEMBL253715 | — | IC50 | = | 97000.0 | nM | 4.01 |
| CHEMBL1290598 | — | IC50 | = | 99000.0 | nM | 4.00 |
| CHEMBL253717 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL267856 | — | IC50 | > | 100000.0 | nM | - |