Assay Detail
Functional
CHEMBL2090730
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Antimalarial activity against liver stages of Plasmodium yoelii 265 BY infected in Swiss mouse after 48 hrs by fluorescence microscopy
13
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Plasmodium yoelii |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Targeting the liver stage of malaria parasites: a yet unmet goal.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 5.40 | 8.35 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2086449 | — | — | 1 | 8.35 |
| CHEMBL506 | PRIMAQUINE | 4.0 | 1 | 7.12 |
| CHEMBL2086394 | — | — | 1 | 5.60 |
| CHEMBL2086450 | — | — | 1 | 5.45 |
| CHEMBL2086451 | — | — | 1 | 5.44 |
| CHEMBL2086446 | — | — | 2 | 5.25 |
| CHEMBL460235 | POLYSYPHORIN | — | 1 | 5.02 |
| CHEMBL2086453 | — | — | 1 | 5.02 |
| CHEMBL2086445 | — | — | 2 | 4.70 |
| CHEMBL2086447 | — | — | 1 | 4.54 |
| CHEMBL2086448 | — | — | 1 | 4.30 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2086449 | — | IC50 | = | 4.5 | nM | 8.35 |
| CHEMBL506 | PRIMAQUINE | IC50 | = | 75.0 | nM | 7.12 |
| CHEMBL2086394 | — | IC50 | = | 2520.0 | nM | 5.60 |
| CHEMBL2086450 | — | IC50 | = | 3540.0 | nM | 5.45 |
| CHEMBL2086451 | — | IC50 | = | 3610.0 | nM | 5.44 |
| CHEMBL2086446 | — | IC50 | = | 5620.0 | nM | 5.25 |
| CHEMBL460235 | POLYSYPHORIN | IC50 | = | 9540.0 | nM | 5.02 |
| CHEMBL2086453 | — | IC50 | = | 9530.0 | nM | 5.02 |
| CHEMBL2086446 | — | IC50 | = | 19000.0 | nM | 4.72 |
| CHEMBL2086445 | — | IC50 | = | 20130.0 | nM | 4.70 |
| CHEMBL2086445 | — | IC50 | = | 20190.0 | nM | 4.70 |
| CHEMBL2086447 | — | IC50 | = | 28610.0 | nM | 4.54 |
| CHEMBL2086448 | — | IC50 | = | 50100.0 | nM | 4.30 |