Assay Detail
Binding
CHEMBL2090926
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]RX821002 from human alpha2B adrenoceptor expressed in CHO cells after 30 mins by scintillation counting
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Low Doses of Allyphenyline and Cyclomethyline, Effective against Morphine Dependence, Elicit an Antidepressant-like Effect.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 6 | 6.40 | 6.47 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL495095 | ALLYPHENYLINE | — | 1 | 6.47 |
| CHEMBL2089155 | — | — | 1 | 6.47 |
| CHEMBL1276140 | — | — | 1 | 6.40 |
| CHEMBL1956195 | CYCLOMETHYLINE | — | 1 | 6.39 |
| CHEMBL2089156 | — | — | 1 | 6.39 |
| CHEMBL1276139 | — | — | 1 | 6.25 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL495095 | ALLYPHENYLINE | Ki | = | 338.84 | nM | 6.47 |
| CHEMBL2089155 | — | Ki | = | 338.84 | nM | 6.47 |
| CHEMBL1276140 | — | Ki | = | 398.11 | nM | 6.40 |
| CHEMBL1956195 | CYCLOMETHYLINE | Ki | = | 407.38 | nM | 6.39 |
| CHEMBL2089156 | — | Ki | = | 407.38 | nM | 6.39 |
| CHEMBL1276139 | — | Ki | = | 562.34 | nM | 6.25 |