Assay Detail
Functional
CHEMBL2090927
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Agonist activity at human alpha2B adrenoceptor expressed in CHO cells assessed as extracellular acidification measured after 4 mins by cytosensor microphysiometric analysis
6
Total Activities
6
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Low Doses of Allyphenyline and Cyclomethyline, Effective against Morphine Dependence, Elicit an Antidepressant-like Effect.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 4 | 5.67 | 6.00 |
| pEC50 | 2 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1276140 | — | — | 1 | 6.00 |
| CHEMBL2089156 | — | — | 1 | 5.80 |
| CHEMBL1956195 | CYCLOMETHYLINE | — | 1 | 5.48 |
| CHEMBL2089155 | — | — | 1 | 5.40 |
| CHEMBL495095 | ALLYPHENYLINE | — | 1 | - |
| CHEMBL1276139 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1276140 | — | EC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL2089156 | — | EC50 | = | 1584.89 | nM | 5.80 |
| CHEMBL1956195 | CYCLOMETHYLINE | EC50 | = | 3311.31 | nM | 5.48 |
| CHEMBL2089155 | — | EC50 | = | 3981.07 | nM | 5.40 |
| CHEMBL495095 | ALLYPHENYLINE | pEC50 | - | — | - | |
| CHEMBL1276139 | — | pEC50 | - | — | - |