Assay Detail
Binding
CHEMBL2091129
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human recombinant p38alpha expressed in Escherichia coli using ATF2 as a substrate by radioisotopic protein kinase assay
36
Total Activities
36
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis and biological evaluation of 2-benzylamino-4(5)-(6-methylpyridin-2-yl)-5(4)-([1,2,4]triazolo[1,5-a]-pyridin-6-yl)thiazoles as transforming growth factor-β type 1 receptor kinase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 36 | 5.39 | 6.32 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL492634 | — | — | 1 | 6.32 |
| CHEMBL226838 | — | — | 1 | 6.23 |
| CHEMBL2087967 | — | — | 1 | 5.48 |
| CHEMBL2087966 | — | — | 1 | 5.45 |
| CHEMBL2087983 | — | — | 1 | 5.45 |
| CHEMBL2087971 | — | — | 1 | 5.42 |
| CHEMBL2087984 | — | — | 1 | 5.42 |
| CHEMBL2087968 | — | — | 1 | 5.27 |
| CHEMBL2087965 | — | — | 1 | 5.26 |
| CHEMBL2087979 | — | — | 1 | 5.23 |
| CHEMBL2088219 | — | — | 1 | 5.21 |
| CHEMBL2087982 | — | — | 1 | 5.14 |
| CHEMBL2087970 | — | — | 1 | 5.13 |
| CHEMBL2088218 | — | — | 1 | 5.10 |
| CHEMBL2088221 | — | — | 1 | 5.05 |
| CHEMBL2087972 | — | — | 1 | 5.04 |
| CHEMBL2087978 | — | — | 1 | - |
| CHEMBL2088224 | — | — | 1 | - |
| CHEMBL2088223 | — | — | 1 | - |
| CHEMBL2088222 | — | — | 1 | - |
| CHEMBL2087969 | — | — | 1 | - |
| CHEMBL2088220 | — | — | 1 | - |
| CHEMBL2087973 | — | — | 1 | - |
| CHEMBL2087974 | — | — | 1 | - |
| CHEMBL2087975 | — | — | 1 | - |
| CHEMBL2087976 | — | — | 1 | - |
| CHEMBL2087977 | — | — | 1 | - |
| CHEMBL2088217 | — | — | 1 | - |
| CHEMBL2087980 | — | — | 1 | - |
| CHEMBL2087981 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL492634 | — | IC50 | = | 480.0 | nM | 6.32 |
| CHEMBL226838 | — | IC50 | = | 594.0 | nM | 6.23 |
| CHEMBL2087967 | — | IC50 | = | 3280.0 | nM | 5.48 |
| CHEMBL2087966 | — | IC50 | = | 3530.0 | nM | 5.45 |
| CHEMBL2087983 | — | IC50 | = | 3580.0 | nM | 5.45 |
| CHEMBL2087971 | — | IC50 | = | 3780.0 | nM | 5.42 |
| CHEMBL2087984 | — | IC50 | = | 3820.0 | nM | 5.42 |
| CHEMBL2087968 | — | IC50 | = | 5370.0 | nM | 5.27 |
| CHEMBL2087965 | — | IC50 | = | 5530.0 | nM | 5.26 |
| CHEMBL2087979 | — | IC50 | = | 5860.0 | nM | 5.23 |
| CHEMBL2088219 | — | IC50 | = | 6190.0 | nM | 5.21 |
| CHEMBL2087982 | — | IC50 | = | 7200.0 | nM | 5.14 |
| CHEMBL2087970 | — | IC50 | = | 7390.0 | nM | 5.13 |
| CHEMBL2088218 | — | IC50 | = | 7990.0 | nM | 5.10 |
| CHEMBL2088221 | — | IC50 | = | 8820.0 | nM | 5.05 |
| CHEMBL2087972 | — | IC50 | = | 9200.0 | nM | 5.04 |
| CHEMBL2088216 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL2088215 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL2088214 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL2088213 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL2087986 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL2087985 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL2087981 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL2087980 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL2088217 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL2087977 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL2087976 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL2087975 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL2087974 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL2087973 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL2088220 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL2087969 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL2088222 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL2088223 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL2088224 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL2087978 | — | IC50 | > | 10000.0 | nM | - |