Assay Detail
Binding
CHEMBL2091179
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Inhibition of recombinant human 15-lipoxygenase by MBTH-DMAB method
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Polyunsaturated fatty acid lipoxygenase ALOX15 (CHEMBL2903) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Synthesis and SAR studies of mono O-prenylated coumarins as potent 15-lipoxygenase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 4.89 | 5.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2088235 | — | — | 1 | 5.89 |
| CHEMBL2088234 | — | — | 1 | 5.44 |
| CHEMBL2088232 | — | — | 1 | 5.17 |
| CHEMBL2088231 | — | — | 1 | 4.89 |
| CHEMBL2088236 | — | — | 1 | 4.81 |
| CHEMBL156127 | UMBELLIPRENIN | — | 1 | 4.78 |
| CHEMBL307341 | AURAPTENE | — | 1 | 4.62 |
| CHEMBL177085 | — | — | 1 | 4.54 |
| CHEMBL2088233 | — | — | 1 | 4.40 |
| CHEMBL2088230 | — | — | 1 | 4.37 |
| CHEMBL2086412 | — | — | 1 | - |
| CHEMBL1834532 | — | — | 1 | - |
| CHEMBL2088237 | FARNESYL PHENYL ETHER | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2088235 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL2088234 | — | IC50 | = | 3600.0 | nM | 5.44 |
| CHEMBL2088232 | — | IC50 | = | 6800.0 | nM | 5.17 |
| CHEMBL2088231 | — | IC50 | = | 12800.0 | nM | 4.89 |
| CHEMBL2088236 | — | IC50 | = | 15600.0 | nM | 4.81 |
| CHEMBL156127 | UMBELLIPRENIN | IC50 | = | 16700.0 | nM | 4.78 |
| CHEMBL307341 | AURAPTENE | IC50 | = | 23900.0 | nM | 4.62 |
| CHEMBL177085 | — | IC50 | = | 28800.0 | nM | 4.54 |
| CHEMBL2088233 | — | IC50 | = | 39500.0 | nM | 4.40 |
| CHEMBL2088230 | — | IC50 | = | 42600.0 | nM | 4.37 |
| CHEMBL2086412 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL1834532 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL2088237 | FARNESYL PHENYL ETHER | IC50 | > | 50000.0 | nM | - |