Assay Detail
Binding
CHEMBL2091585
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Binding affinity to human beta1-adrenoceptor by radioligand binding assay
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
An investigation into the structure-activity relationships associated with the systematic modification of the β(2)-adrenoceptor agonist indacaterol.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 10 | 6.71 | 8.72 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2088201 | — | — | 1 | 8.72 |
| CHEMBL2088202 | — | — | 1 | 6.88 |
| CHEMBL1346 | DARIFENACIN | 4.0 | 1 | 6.75 |
| CHEMBL2088197 | — | — | 1 | 6.74 |
| CHEMBL2088196 | — | — | 1 | 6.64 |
| CHEMBL2088199 | — | — | 1 | 6.59 |
| CHEMBL2088200 | — | — | 1 | 6.38 |
| CHEMBL2088198 | — | — | 1 | 6.32 |
| CHEMBL82663 | SIBENADET | 2.0 | 1 | 5.41 |
| CHEMBL2088195 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2088201 | — | Ki | = | 1.9 | nM | 8.72 |
| CHEMBL2088202 | — | Ki | = | 133.0 | nM | 6.88 |
| CHEMBL1346 | DARIFENACIN | Ki | = | 180.0 | nM | 6.75 |
| CHEMBL2088197 | — | Ki | = | 183.0 | nM | 6.74 |
| CHEMBL2088196 | — | Ki | = | 227.0 | nM | 6.64 |
| CHEMBL2088199 | — | Ki | = | 259.0 | nM | 6.59 |
| CHEMBL2088200 | — | Ki | = | 421.0 | nM | 6.38 |
| CHEMBL2088198 | — | Ki | = | 478.0 | nM | 6.32 |
| CHEMBL82663 | SIBENADET | Ki | = | 3922.0 | nM | 5.41 |
| CHEMBL2088195 | — | Ki | > | 10000.0 | nM | - |