Assay Detail
Functional
CHEMBL2091663
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Antiproliferative activity against human HCT116 cells after 3 days by MTT assay
22
Total Activities
22
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HCT-116 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis and preliminary bioevaluation of novel E-ring modified acetal analog of camptothecin as cytotoxic agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 22 | 6.65 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2089141 | — | — | 1 | 9.00 |
| CHEMBL2089142 | — | — | 1 | 9.00 |
| CHEMBL2089140 | — | — | 1 | 7.25 |
| CHEMBL2089138 | — | — | 1 | 7.14 |
| CHEMBL84 | TOPOTECAN | 4.0 | 1 | 7.05 |
| CHEMBL2089133 | — | — | 1 | 7.04 |
| CHEMBL65 | CAMPTOTHECIN | -1.0 | 1 | 6.96 |
| CHEMBL2089134 | — | — | 1 | 6.93 |
| CHEMBL2089129 | — | — | 1 | 6.90 |
| CHEMBL2089130 | — | — | 1 | 6.68 |
| CHEMBL2089135 | — | — | 1 | 6.63 |
| CHEMBL2089136 | — | — | 1 | 6.60 |
| CHEMBL2089139 | — | — | 1 | 6.58 |
| CHEMBL2089137 | — | — | 1 | 6.51 |
| CHEMBL2089132 | — | — | 1 | 6.48 |
| CHEMBL2088017 | — | — | 1 | 6.39 |
| CHEMBL2089126 | — | — | 1 | 6.29 |
| CHEMBL2088015 | — | — | 1 | 6.27 |
| CHEMBL2088016 | — | — | 1 | 5.09 |
| CHEMBL2089127 | — | — | 1 | 4.94 |
| CHEMBL2089128 | — | — | 1 | 4.02 |
| CHEMBL2089131 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2089141 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL2089142 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL2089140 | — | IC50 | = | 56.9 | nM | 7.25 |
| CHEMBL2089138 | — | IC50 | = | 73.0 | nM | 7.14 |
| CHEMBL84 | TOPOTECAN | IC50 | = | 88.9 | nM | 7.05 |
| CHEMBL2089133 | — | IC50 | = | 90.2 | nM | 7.04 |
| CHEMBL65 | CAMPTOTHECIN | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL2089134 | — | IC50 | = | 117.0 | nM | 6.93 |
| CHEMBL2089129 | — | IC50 | = | 127.0 | nM | 6.90 |
| CHEMBL2089130 | — | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL2089135 | — | IC50 | = | 236.0 | nM | 6.63 |
| CHEMBL2089136 | — | IC50 | = | 249.0 | nM | 6.60 |
| CHEMBL2089139 | — | IC50 | = | 264.0 | nM | 6.58 |
| CHEMBL2089137 | — | IC50 | = | 309.0 | nM | 6.51 |
| CHEMBL2089132 | — | IC50 | = | 333.0 | nM | 6.48 |
| CHEMBL2088017 | — | IC50 | = | 406.0 | nM | 6.39 |
| CHEMBL2089126 | — | IC50 | = | 517.0 | nM | 6.29 |
| CHEMBL2088015 | — | IC50 | = | 532.0 | nM | 6.27 |
| CHEMBL2088016 | — | IC50 | = | 8170.0 | nM | 5.09 |
| CHEMBL2089127 | — | IC50 | = | 11490.0 | nM | 4.94 |
| CHEMBL2089128 | — | IC50 | = | 95090.0 | nM | 4.02 |
| CHEMBL2089131 | — | IC50 | > | 100000.0 | nM | - |