Assay Detail

CHEMBL2091665

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Functional

Antiproliferative activity against human ZR75-30 cells after 3 days by MTT assay

ChEMBL ↗

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Target

ZR-75-30 (CHEMBL1075613) ↗

Open DB target context

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ZR-75-30 (CHEMBL1075613) is the working anchor for this assay review. Loading the live Open DB target snapshot…

Primary target ZR-75-30

CHEMBL1075613

Anchored from Assay target.

Protein identity ZR-75-30

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Functional
Organism	Homo sapiens
Cell Type	ZR-75-30
Confidence	1 — Organism
Curated By	Autocuration

Target

ZR-75-30 (CHEMBL1075613) ↗

Type	CELL-LINE
Organism	Homo sapiens

Publication

Synthesis and preliminary bioevaluation of novel E-ring modified acetal analog of camptothecin as cytotoxic agents.

Zhu L, Zhuang C, Lei N, Guo Z, Sheng C, Dong G, Wang S, Zhang Y, Yao J, Miao Z, Zhang W.
Eur J Med Chem (2012) 56 : 1 -9
PubMed 23084702 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
IC50	1	6.91	6.91

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL2089142	—	—	1	6.91

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL2089142	—	IC50	=	122.0	nM	6.91