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Assay Detail

CHEMBL2091941

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Cytotoxicity against human HCT15 cells by SRB assay
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type HCT-15
Confidence 1 — Organism
Curated By Autocuration

Target

HCT-15 (CHEMBL612263)
Type CELL-LINE
Organism Homo sapiens

Publication

Phenolic constituents from the rhizomes of Acorus gramineus and their biological evaluation on antitumor and anti-inflammatory activities.
Kim KH, Moon E, Kim HK, Oh JY, Kim SY, Choi SU, Lee KR.
Bioorg Med Chem Lett (2012) 22 : 6155 -6159
PubMed 22951040 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 14 5.05 7.09

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL53463 DOXORUBICIN 4.0 1 7.09
CHEMBL2088627 SURINAMENSINOL B 1 4.72
CHEMBL2088631 1 4.69
CHEMBL156339 MAGNOSALIN 1 4.64
CHEMBL2088626 1 4.61
CHEMBL2088633 1 4.57
CHEMBL2088628 1 -
CHEMBL2088629 1 -
CHEMBL465182 1 -
CHEMBL206555 N-TRANS-FERULOYL TYRAMINE 1 -
CHEMBL451720 1 -
CHEMBL2088630 ACORAMOL 1 -
CHEMBL2088632 1 -
CHEMBL1417159 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL53463 DOXORUBICIN IC50 = 82.0 nM 7.09
CHEMBL2088627 SURINAMENSINOL B IC50 = 18830.0 nM 4.72
CHEMBL2088631 IC50 = 20350.0 nM 4.69
CHEMBL156339 MAGNOSALIN IC50 = 23050.0 nM 4.64
CHEMBL2088626 IC50 = 24330.0 nM 4.61
CHEMBL2088633 IC50 = 26640.0 nM 4.57
CHEMBL2088628 IC50 > 30000.0 nM -
CHEMBL2088629 IC50 > 30000.0 nM -
CHEMBL465182 IC50 > 30000.0 nM -
CHEMBL206555 N-TRANS-FERULOYL TYRAMINE IC50 > 30000.0 nM -
CHEMBL451720 IC50 > 30000.0 nM -
CHEMBL2088630 ACORAMOL IC50 > 30000.0 nM -
CHEMBL2088632 IC50 > 30000.0 nM -
CHEMBL1417159 IC50 > 30000.0 nM -