Skip to main content
Free research Free research Free assay review with research home and workspace preview
Quick search ChEMBL 36
Assay Detail

CHEMBL2091981

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Activation of rat TRPV3 expressed in HEK293 cells assessed as stimulation of intracellular Ca2+ levels
35
Total Activities
35
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Rattus norvegicus
Cell Type HEK293
Confidence 0 — Uncurated / Unknown
Curated By Autocuration

Target

Unchecked (CHEMBL612545)
Type UNCHECKED

Publication

Modulation of thermo-transient receptor potential (thermo-TRP) channels by thymol-based compounds.
Ortar G, Morera L, Moriello AS, Morera E, Nalli M, Di Marzo V, De Petrocellis L.
Bioorg Med Chem Lett (2012) 22 : 3535 -3539
PubMed 22503249 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
EC50 35 5.10 6.10

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL2087060 1 6.10
CHEMBL2087052 1 5.92
CHEMBL2087065 1 5.85
CHEMBL2087070 1 5.60
CHEMBL2087054 1 5.44
CHEMBL2087047 1 5.42
CHEMBL2087051 1 5.40
CHEMBL2087046 1 5.31
CHEMBL2087068 1 5.28
CHEMBL2087043 1 5.24
CHEMBL2087073 1 5.23
CHEMBL2087062 1 5.20
CHEMBL2087072 1 5.12
CHEMBL2087045 1 5.11
CHEMBL2087059 1 4.97
CHEMBL2087055 1 4.93
CHEMBL2087048 1 4.91
CHEMBL2087049 1 4.84
CHEMBL2087071 1 4.82
CHEMBL2087063 1 4.80
CHEMBL2087050 1 4.68
CHEMBL2087044 1 4.67
CHEMBL2087067 1 4.46
CHEMBL2087053 1 4.22
CHEMBL29411 THYMOL 2.0 1 4.08
CHEMBL2087075 1 -
CHEMBL2087074 1 -
CHEMBL1385022 1 -
CHEMBL2087061 1 -
CHEMBL2087069 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL2087060 EC50 = 800.0 nM 6.10
CHEMBL2087052 EC50 = 1200.0 nM 5.92
CHEMBL2087065 EC50 = 1400.0 nM 5.85
CHEMBL2087070 EC50 = 2500.0 nM 5.60
CHEMBL2087054 EC50 = 3600.0 nM 5.44
CHEMBL2087047 EC50 = 3800.0 nM 5.42
CHEMBL2087051 EC50 = 4000.0 nM 5.40
CHEMBL2087046 EC50 = 4900.0 nM 5.31
CHEMBL2087068 EC50 = 5200.0 nM 5.28
CHEMBL2087043 EC50 = 5700.0 nM 5.24
CHEMBL2087073 EC50 = 5900.0 nM 5.23
CHEMBL2087062 EC50 = 6300.0 nM 5.20
CHEMBL2087072 EC50 = 7600.0 nM 5.12
CHEMBL2087045 EC50 = 7700.0 nM 5.11
CHEMBL2087059 EC50 = 10600.0 nM 4.97
CHEMBL2087055 EC50 = 11800.0 nM 4.93
CHEMBL2087048 EC50 = 12200.0 nM 4.91
CHEMBL2087049 EC50 = 14500.0 nM 4.84
CHEMBL2087071 EC50 = 15100.0 nM 4.82
CHEMBL2087063 EC50 = 15900.0 nM 4.80
CHEMBL2087050 EC50 = 20900.0 nM 4.68
CHEMBL2087044 EC50 = 21400.0 nM 4.67
CHEMBL2087067 EC50 = 34300.0 nM 4.46
CHEMBL2087053 EC50 = 59700.0 nM 4.22
CHEMBL29411 THYMOL EC50 = 84100.0 nM 4.08
CHEMBL2087056 EC50 - -
CHEMBL2087057 EC50 - -
CHEMBL2087064 EC50 - -
CHEMBL2087058 EC50 - -
CHEMBL2087066 EC50 - -
CHEMBL2087069 EC50 - -
CHEMBL2087061 EC50 - -
CHEMBL1385022 EC50 - -
CHEMBL2087074 EC50 - -
CHEMBL2087075 EC50 - -