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Compound Detail

CHEMBL2087073

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Cc1ccc(C(C)C)c(NC(=O)Nc2ccc(-c3ccccc3)cc2)c1
ChEMBL ↗ Properties Compare Identifier

Basic Information

ChEMBL ID CHEMBL2087073
Phase Preclinical
Structure Type MOL
InChI Key ZQLWJUGZXBQKRM-UHFFFAOYSA-N
3
Targets
6
Activities
2
Assay Types
0
PK Parameters
3
Publications
0
Known Names

Molecular Properties

344.5
MW (Da)
6.43
ALogP
1
HBA
2
HBD
41.1
PSA (Ų)
0.56
QED
1
Ro5 Violations
4
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C23H24N2O
MW 344.46
Aromatic Rings 3
Heavy Atoms 26
NP-Likeness -1.23

Activity Summary

IC50 4 meas. best 4.89
EC50 2 meas. best 5.23

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Unchecked
CHEMBL612545
 EC50 5.23 5.23 5900.0 1
Unchecked
CHEMBL612545
 IC50 4.89 4.89 12800.0 1
Transient receptor potential cation channel subfamily M member 8
CHEMBL5011
 IC50 4.59 4.51 25400.0 2
Transient receptor potential cation channel subfamily A member 1
CHEMBL5160
 IC50 4.55 4.55 27900.0 1
Transient receptor potential cation channel subfamily A member 1
CHEMBL5160
 EC50 4.49 4.49 32200.0 1

Activity Data Samples

Top measurements by pChEMBL value

Target Type Rel. Value Units pChEMBL Assay PubMed
Unchecked EC50 = 5900.0 nM 5.23 Activation of rat TRPV3 expressed in HEK293 cells assessed as stimulation of int... 22503249
Unchecked IC50 = 12800.0 nM 4.89 Inhibition of rat TRPV3 expressed in HEK293 cells assessed as reduction in 100 u... 22503249
Transient receptor potential cation channel subfamily M member 8 IC50 = 25400.0 nM 4.59 Inhibition of rat TRPM8 expressed in HEK293 cells assessed as reduction in 20 uM... 22503249
Transient receptor potential cation channel subfamily A member 1 IC50 = 27900.0 nM 4.55 Inhibition of rat TRPA1 expressed in HEK293 cells assessed as reduction in 100 u... 22503249
Transient receptor potential cation channel subfamily A member 1 EC50 = 32200.0 nM 4.49 Activation of rat TRPA1 expressed in HEK293 cells assessed as stimulation of int... 22503249
Transient receptor potential cation channel subfamily M member 8 IC50 = 37400.0 nM 4.43 Inhibition of rat TRPM8 expressed in HEK293 cells assessed as reduction in 0.25 ... 22503249

Literature References

PubMed DOI Target Context # Activities
22503249 10.1016/j.bmcl.2012.03.055 Unchecked 4
22503249 10.1016/j.bmcl.2012.03.055 Transient receptor potential cation channel subfamily M member 8 4
22503249 10.1016/j.bmcl.2012.03.055 Transient receptor potential cation channel subfamily A member 1 3

Data from ChEMBL 36 via Core Engine