Assay Detail
Binding
CHEMBL2091979
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of rat TRPM8 expressed in HEK293 cells assessed as reduction in 20 uM menthol-stimulated increase in intracellular Ca2+ levels
35
Total Activities
35
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Transient receptor potential cation channel subfamily M member 8 (CHEMBL5011) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Modulation of thermo-transient receptor potential (thermo-TRP) channels by thymol-based compounds.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 35 | 5.06 | 6.50 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2087057 | — | — | 1 | 6.50 |
| CHEMBL2087065 | — | — | 1 | 6.07 |
| CHEMBL2087064 | — | — | 1 | 6.05 |
| CHEMBL2087059 | — | — | 1 | 6.00 |
| CHEMBL2087052 | — | — | 1 | 5.92 |
| CHEMBL2087056 | — | — | 1 | 5.55 |
| CHEMBL2087054 | — | — | 1 | 5.47 |
| CHEMBL2087043 | — | — | 1 | 5.44 |
| CHEMBL2087060 | — | — | 1 | 5.39 |
| CHEMBL2087053 | — | — | 1 | 5.36 |
| CHEMBL2087046 | — | — | 1 | 5.30 |
| CHEMBL2087055 | — | — | 1 | 5.30 |
| CHEMBL1385022 | — | — | 1 | 5.28 |
| CHEMBL2087070 | — | — | 1 | 5.21 |
| CHEMBL2087069 | — | — | 1 | 4.98 |
| CHEMBL2087071 | — | — | 1 | 4.93 |
| CHEMBL2087067 | — | — | 1 | 4.86 |
| CHEMBL2087063 | — | — | 1 | 4.85 |
| CHEMBL2087061 | — | — | 1 | 4.82 |
| CHEMBL2087068 | — | — | 1 | 4.79 |
| CHEMBL2087045 | — | — | 1 | 4.73 |
| CHEMBL2087073 | — | — | 1 | 4.59 |
| CHEMBL2087072 | — | — | 1 | 4.57 |
| CHEMBL2087044 | — | — | 1 | 4.24 |
| CHEMBL2087058 | — | — | 1 | 4.21 |
| CHEMBL2087066 | — | — | 1 | 4.13 |
| CHEMBL2087051 | — | — | 1 | 4.11 |
| CHEMBL2087074 | — | — | 1 | 4.11 |
| CHEMBL2087062 | — | — | 1 | 4.11 |
| CHEMBL2087050 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2087057 | — | IC50 | = | 320.0 | nM | 6.50 |
| CHEMBL2087065 | — | IC50 | = | 850.0 | nM | 6.07 |
| CHEMBL2087064 | — | IC50 | = | 900.0 | nM | 6.05 |
| CHEMBL2087059 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL2087052 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL2087056 | — | IC50 | = | 2800.0 | nM | 5.55 |
| CHEMBL2087054 | — | IC50 | = | 3400.0 | nM | 5.47 |
| CHEMBL2087043 | — | IC50 | = | 3600.0 | nM | 5.44 |
| CHEMBL2087060 | — | IC50 | = | 4100.0 | nM | 5.39 |
| CHEMBL2087053 | — | IC50 | = | 4400.0 | nM | 5.36 |
| CHEMBL2087046 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL2087055 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL1385022 | — | IC50 | = | 5200.0 | nM | 5.28 |
| CHEMBL2087070 | — | IC50 | = | 6100.0 | nM | 5.21 |
| CHEMBL2087069 | — | IC50 | = | 10400.0 | nM | 4.98 |
| CHEMBL2087071 | — | IC50 | = | 11700.0 | nM | 4.93 |
| CHEMBL2087067 | — | IC50 | = | 13900.0 | nM | 4.86 |
| CHEMBL2087063 | — | IC50 | = | 14100.0 | nM | 4.85 |
| CHEMBL2087061 | — | IC50 | = | 15200.0 | nM | 4.82 |
| CHEMBL2087068 | — | IC50 | = | 16200.0 | nM | 4.79 |
| CHEMBL2087045 | — | IC50 | = | 18600.0 | nM | 4.73 |
| CHEMBL2087073 | — | IC50 | = | 25400.0 | nM | 4.59 |
| CHEMBL2087072 | — | IC50 | = | 26700.0 | nM | 4.57 |
| CHEMBL2087044 | — | IC50 | = | 57800.0 | nM | 4.24 |
| CHEMBL2087058 | — | IC50 | = | 61400.0 | nM | 4.21 |
| CHEMBL2087066 | — | IC50 | = | 73700.0 | nM | 4.13 |
| CHEMBL2087051 | — | IC50 | = | 77400.0 | nM | 4.11 |
| CHEMBL2087062 | — | IC50 | = | 78300.0 | nM | 4.11 |
| CHEMBL2087074 | — | IC50 | = | 77500.0 | nM | 4.11 |
| CHEMBL2087050 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL2087049 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL2087048 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL2087047 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL2087075 | — | IC50 | = | 113400.0 | nM | - |
| CHEMBL29411 | THYMOL | IC50 | = | 169100.0 | nM | - |