Assay Detail
Functional
CHEMBL2091987
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Antiproliferative activity against human HCT116 cells after 72 hrs by CellTiterGlo assay
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HCT-116 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of novel allosteric mitogen-activated protein kinase kinase (MEK) 1,2 inhibitors possessing bidentate Ser212 interactions.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 9 | 7.07 | 7.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2087076 | — | — | 1 | 7.80 |
| CHEMBL2087080 | — | — | 1 | 7.51 |
| CHEMBL2087461 | — | — | 1 | 7.36 |
| CHEMBL2087462 | — | — | 1 | 7.21 |
| CHEMBL2087081 | — | — | 1 | 6.90 |
| CHEMBL2087082 | — | — | 1 | 6.88 |
| CHEMBL2087078 | — | — | 1 | 6.76 |
| CHEMBL2087079 | — | — | 1 | 6.71 |
| CHEMBL2087077 | — | — | 1 | 6.50 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2087076 | — | EC50 | = | 16.0 | nM | 7.80 |
| CHEMBL2087080 | — | EC50 | = | 31.0 | nM | 7.51 |
| CHEMBL2087461 | — | EC50 | = | 44.0 | nM | 7.36 |
| CHEMBL2087462 | — | EC50 | = | 62.0 | nM | 7.21 |
| CHEMBL2087081 | — | EC50 | = | 127.0 | nM | 6.90 |
| CHEMBL2087082 | — | EC50 | = | 132.0 | nM | 6.88 |
| CHEMBL2087078 | — | EC50 | = | 175.0 | nM | 6.76 |
| CHEMBL2087079 | — | EC50 | = | 193.0 | nM | 6.71 |
| CHEMBL2087077 | — | EC50 | = | 314.0 | nM | 6.50 |