Assay Detail
Functional
CHEMBL2092262
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Antiproliferative activity against human HCT116 cells after 72 hrs by MTS assay
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HCT-116 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Structure-based design of novel potent protein kinase CK2 (CK2) inhibitors with phenyl-azole scaffolds.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 5.23 | 5.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2087023 | — | — | 1 | 5.80 |
| CHEMBL1230165 | SILMITASERTIB | 2.0 | 1 | 5.28 |
| CHEMBL2048144 | — | — | 1 | 4.62 |
| CHEMBL2087008 | — | — | 1 | - |
| CHEMBL2087025 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2087023 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL1230165 | SILMITASERTIB | IC50 | = | 5200.0 | nM | 5.28 |
| CHEMBL2048144 | — | IC50 | = | 24000.0 | nM | 4.62 |
| CHEMBL2087008 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL2087025 | — | IC50 | > | 30000.0 | nM | - |