Assay Detail
Functional
CHEMBL2092374
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of epithelial growth factor-induced cell migration of human MDA-MB-231 cells pre-incubated for 24 hrs by cell invasion assay
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MDA-MB-231 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Alkaloids from Pachysandra terminalis inhibit breast cancer invasion and have potential for development as antimetastasis therapeutic agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 6.55 | 7.16 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2087203 | TERMINAMINE E | — | 1 | 7.16 |
| CHEMBL2087201 | TERMINAMINE C | — | 1 | 7.10 |
| CHEMBL2087199 | TERMINAMINE A | — | 1 | 6.75 |
| CHEMBL2087206 | PACHYSTERMINE B | — | 1 | 6.72 |
| CHEMBL2087200 | TERMINAMINE B | — | 1 | 6.70 |
| CHEMBL2087202 | TERMINAMINE D | — | 1 | 6.70 |
| CHEMBL2087207 | PACHYSTERMINE A | — | 1 | 6.50 |
| CHEMBL2087209 | EPIPACHYSAMINE B | — | 1 | 6.46 |
| CHEMBL2087212 | TERMINALINE | — | 1 | 6.44 |
| CHEMBL98350 | LY-294002 | -1.0 | 1 | 6.42 |
| CHEMBL2087208 | EPIPACHYSAMINE E | — | 1 | 6.39 |
| CHEMBL2087210 | — | — | 1 | 6.06 |
| CHEMBL2087211 | Z-salignone | — | 1 | 5.76 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2087203 | TERMINAMINE E | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL2087201 | TERMINAMINE C | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL2087199 | TERMINAMINE A | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL2087206 | PACHYSTERMINE B | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL2087200 | TERMINAMINE B | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL2087202 | TERMINAMINE D | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL2087207 | PACHYSTERMINE A | IC50 | = | 320.0 | nM | 6.50 |
| CHEMBL2087209 | EPIPACHYSAMINE B | IC50 | = | 350.0 | nM | 6.46 |
| CHEMBL2087212 | TERMINALINE | IC50 | = | 360.0 | nM | 6.44 |
| CHEMBL98350 | LY-294002 | IC50 | = | 380.0 | nM | 6.42 |
| CHEMBL2087208 | EPIPACHYSAMINE E | IC50 | = | 410.0 | nM | 6.39 |
| CHEMBL2087210 | — | IC50 | = | 870.0 | nM | 6.06 |
| CHEMBL2087211 | Z-salignone | IC50 | = | 1740.0 | nM | 5.76 |