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Assay Detail

CHEMBL2092447

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Inhibition of LPS-induced TNFalpha production in human whole blood
33
Total Activities
33
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Tissue Blood
Confidence 1 — Organism
Curated By Autocuration

Target

Blood (CHEMBL613416)
Type TISSUE
Organism Homo sapiens

Publication

Novel triazolopyridylbenzamides as potent and selective p38α inhibitors.
Aiguadé J, Balagué C, Carranco I, Caturla F, Domínguez M, Eastwood P, Esteve C, González J, Lumeras W, Orellana A, Preciado S, Roca R, Vidal L, Vidal B.
Bioorg Med Chem Lett (2012) 22 : 3431 -3436
PubMed 22521646 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 33 6.73 8.14

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL2087513 1 8.14
CHEMBL2087512 1 7.70
CHEMBL2087504 1 7.60
CHEMBL2087500 1 7.52
CHEMBL2087502 1 7.38
CHEMBL2087501 1 7.32
CHEMBL2087524 1 7.08
CHEMBL2087515 1 7.08
CHEMBL2087499 1 7.01
CHEMBL2087526 1 6.98
CHEMBL2087503 1 6.94
CHEMBL2087742 1 6.94
CHEMBL2087507 1 6.93
CHEMBL2087747 1 6.91
CHEMBL1198626 1 6.84
CHEMBL2087521 1 6.75
CHEMBL2087505 1 6.67
CHEMBL2087506 1 6.63
CHEMBL2087517 1 6.59
CHEMBL2087522 1 6.56
CHEMBL2087514 1 6.52
CHEMBL2087511 1 6.39
CHEMBL2087743 1 6.33
CHEMBL2087741 1 6.29
CHEMBL2087509 1 6.26
CHEMBL2087510 1 6.18
CHEMBL2087508 1 6.17
CHEMBL2087746 1 6.08
CHEMBL2087516 1 5.98
CHEMBL2087525 1 5.96

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL2087513 IC50 = 7.2 nM 8.14
CHEMBL2087512 IC50 = 20.0 nM 7.70
CHEMBL2087504 IC50 = 25.0 nM 7.60
CHEMBL2087500 IC50 = 30.0 nM 7.52
CHEMBL2087502 IC50 = 42.0 nM 7.38
CHEMBL2087501 IC50 = 48.0 nM 7.32
CHEMBL2087524 IC50 = 84.0 nM 7.08
CHEMBL2087515 IC50 = 84.0 nM 7.08
CHEMBL2087499 IC50 = 98.0 nM 7.01
CHEMBL2087526 IC50 = 105.0 nM 6.98
CHEMBL2087503 IC50 = 115.0 nM 6.94
CHEMBL2087742 IC50 = 116.0 nM 6.94
CHEMBL2087507 IC50 = 117.0 nM 6.93
CHEMBL2087747 IC50 = 124.0 nM 6.91
CHEMBL1198626 IC50 = 143.0 nM 6.84
CHEMBL2087521 IC50 = 177.0 nM 6.75
CHEMBL2087505 IC50 = 213.0 nM 6.67
CHEMBL2087506 IC50 = 232.0 nM 6.63
CHEMBL2087517 IC50 = 257.0 nM 6.59
CHEMBL2087522 IC50 = 278.0 nM 6.56
CHEMBL2087514 IC50 = 305.0 nM 6.52
CHEMBL2087511 IC50 = 405.0 nM 6.39
CHEMBL2087743 IC50 = 467.0 nM 6.33
CHEMBL2087741 IC50 = 516.0 nM 6.29
CHEMBL2087509 IC50 = 550.0 nM 6.26
CHEMBL2087510 IC50 = 667.0 nM 6.18
CHEMBL2087508 IC50 = 670.0 nM 6.17
CHEMBL2087746 IC50 = 822.0 nM 6.08
CHEMBL2087516 IC50 = 1056.0 nM 5.98
CHEMBL2087525 IC50 = 1110.0 nM 5.96
CHEMBL2087744 IC50 = 1466.0 nM 5.83
CHEMBL2087520 IC50 = 1839.0 nM 5.74
CHEMBL2087745 IC50 > 5000.0 nM -