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Assay Detail

CHEMBL2114893

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
PubChem BioAssay. Dose Response for ABC transporter inhibitors: specifically ABCG2 screen, ABCB1 counter-screen. Follow-up assay.. (Class of assay: confirmatory)
ChEMBL ↗
88
Total Activities
88
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Category confirmatory
Confidence 8 — Homologous single protein target
Curated By Autocuration

Target

Broad substrate specificity ATP-binding cassette transporter ABCG2 (CHEMBL5393) ↗
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

PubChem BioAssay data set

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
EC50 88 9.79 10.99

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL2145384 — — 1 10.99
CHEMBL2141796 — — 1 10.99
CHEMBL2142245 — — 1 10.96
CHEMBL2137928 — — 1 10.92
CHEMBL2141666 — — 1 10.64
CHEMBL2130718 — — 1 10.63
CHEMBL2137680 — — 1 10.39
CHEMBL2140166 — — 1 10.39
CHEMBL2135227 — — 1 10.35
CHEMBL2133727 — — 1 10.32
CHEMBL2132526 — — 1 9.60
CHEMBL2133413 — — 1 8.70
CHEMBL2134322 — — 1 8.04
CHEMBL2141371 — — 1 7.56
CHEMBL2139757 — — 1 6.34
CHEMBL2140364 — — 1 -
CHEMBL2135811 — — 1 -
CHEMBL2135890 — — 1 -
CHEMBL2138737 — — 1 -
CHEMBL2142391 — — 1 -
CHEMBL2131986 — — 1 -
CHEMBL2143182 — — 1 -
CHEMBL2131314 — — 1 -
CHEMBL2138693 — — 1 -
CHEMBL2135979 — — 1 -
CHEMBL2142496 — — 1 -
CHEMBL2144131 — — 1 -
CHEMBL1565753 — — 1 -
CHEMBL2137696 — — 1 -
CHEMBL2134695 — — 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL2145384 — EC50 = 0.01013 nM 10.99
CHEMBL2141796 — EC50 = 0.01019 nM 10.99
CHEMBL2142245 — EC50 = 0.01088 nM 10.96
CHEMBL2137928 — EC50 = 0.01209 nM 10.92
CHEMBL2141666 — EC50 = 0.02297 nM 10.64
CHEMBL2130718 — EC50 = 0.02338 nM 10.63
CHEMBL2137680 — EC50 = 0.04093 nM 10.39
CHEMBL2140166 — EC50 = 0.04032 nM 10.39
CHEMBL2135227 — EC50 = 0.04419 nM 10.35
CHEMBL2133727 — EC50 = 0.04775 nM 10.32
CHEMBL2132526 — EC50 = 0.254 nM 9.60
CHEMBL2133413 — EC50 = 1.999 nM 8.70
CHEMBL2134322 — EC50 = 9.229 nM 8.04
CHEMBL2141371 — EC50 = 27.61 nM 7.56
CHEMBL2139757 — EC50 = 456.5 nM 6.34
CHEMBL2134161 — EC50 = 0.00253 nM -
CHEMBL2136204 — EC50 = 0.00151 nM -
CHEMBL2134144 — EC50 = 0.00602 nM -
CHEMBL2135201 — EC50 = 0.000503 nM -
CHEMBL1565361 — EC50 = 0.00192 nM -
CHEMBL2133181 — EC50 = 0.00192 nM -
CHEMBL2143465 — EC50 = 0.00287 nM -
CHEMBL2137849 — EC50 = 0.0071 nM -
CHEMBL1865934 — EC50 = 0.00046 nM -
CHEMBL2138719 — EC50 = 0.00818 nM -
CHEMBL2142712 — EC50 = 0.00168 nM -
CHEMBL2132333 — EC50 = 0.00159 nM -
CHEMBL2140567 — EC50 = 0.00273 nM -
CHEMBL1900518 — EC50 = 0.00383 nM -
CHEMBL2133117 — EC50 = 0.00344 nM -
CHEMBL1325873 — EC50 = 0.00752 nM -
CHEMBL2132316 — EC50 = 0.001463 nM -
CHEMBL2143182 — EC50 = 0.000613 nM -
CHEMBL2134695 — EC50 = 0.00649 nM -
CHEMBL2137696 — EC50 = 0.00909 nM -
CHEMBL1565753 — EC50 = 0.00143 nM -
CHEMBL2144131 — EC50 = 0.00186 nM -
CHEMBL2142496 — EC50 = 0.0018 nM -
CHEMBL2135979 — EC50 = 0.000852 nM -
CHEMBL2138693 — EC50 = 0.000697 nM -
CHEMBL2131314 — EC50 = 0.000393 nM -
CHEMBL2138028 — EC50 = 0.009315 nM -
CHEMBL2131986 — EC50 = 0.00764 nM -
CHEMBL2142391 — EC50 = 0.00054 nM -
CHEMBL2138737 — EC50 = 0.00182 nM -
CHEMBL2135890 — EC50 = 0.0012 nM -
CHEMBL2135811 — EC50 = 0.00364 nM -
CHEMBL2140364 — EC50 = 0.00268 nM -
CHEMBL2136710 — EC50 = 0.00169 nM -
CHEMBL2138767 — EC50 = 0.00211 nM -