Assay Detail
Binding
CHEMBL2148510
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Inhibition of His-tagged PTPsigma catalytic domain amino acid 1369 to 1948 using DiFMUP as substrate after 20 mins by spectrofluorometric analysis
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Discovery of potent inhibitors of receptor protein tyrosine phosphatase sigma through the structure-based virtual screening.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 6.28 | 7.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2146956 | — | — | 1 | 7.00 |
| CHEMBL399586 | — | — | 1 | 6.70 |
| CHEMBL2146957 | — | — | 1 | 6.22 |
| CHEMBL2146960 | — | — | 1 | 6.16 |
| CHEMBL2146958 | — | — | 1 | 6.05 |
| CHEMBL2057830 | — | — | 1 | 5.92 |
| CHEMBL2146959 | — | — | 1 | 5.89 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2146956 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL399586 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL2146957 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL2146960 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL2146958 | — | IC50 | = | 900.0 | nM | 6.05 |
| CHEMBL2057830 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL2146959 | — | IC50 | = | 1300.0 | nM | 5.89 |