Assay Detail
Binding
CHEMBL2148592
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Inhibition of human amyloid beta (1 to 42) aggregation after 24 hrs by thioflavin-T fluorescence assay
13
Total Activities
11
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Protective effects of caffeoylquinic acids on the aggregation and neurotoxicity of the 42-residue amyloid β-protein.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 5.42 | 7.00 |
| Inhibition | 2 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL177126 | — | — | 1 | 7.00 |
| CHEMBL499997 | — | — | 1 | 6.52 |
| CHEMBL2146607 | — | — | 1 | 5.66 |
| CHEMBL2146608 | — | — | 1 | 5.52 |
| CHEMBL249448 | — | — | 1 | 5.33 |
| CHEMBL249447 | — | — | 1 | 4.79 |
| CHEMBL145 | CAFFEIC ACID | 3.0 | 2 | 4.48 |
| CHEMBL284616 | CHLOROGENIC ACID | 2.0 | 2 | 4.03 |
| CHEMBL465398 | QUINIC ACID | — | 1 | - |
| CHEMBL27246 | CINNAMIC ACID | — | 1 | - |
| CHEMBL416955 | CHLOROGENIC ACID METHYL ESTER | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL177126 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL499997 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL2146607 | — | IC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL2146608 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL249448 | — | IC50 | = | 4700.0 | nM | 5.33 |
| CHEMBL249447 | — | IC50 | = | 16400.0 | nM | 4.79 |
| CHEMBL145 | CAFFEIC ACID | IC50 | = | 32800.0 | nM | 4.48 |
| CHEMBL284616 | CHLOROGENIC ACID | IC50 | = | 92900.0 | nM | 4.03 |
| CHEMBL465398 | QUINIC ACID | IC50 | > | 100000.0 | nM | - |
| CHEMBL27246 | CINNAMIC ACID | IC50 | > | 100000.0 | nM | - |
| CHEMBL416955 | CHLOROGENIC ACID METHYL ESTER | IC50 | > | 100000.0 | nM | - |
| CHEMBL145 | CAFFEIC ACID | Inhibition | - | % | - | |
| CHEMBL284616 | CHLOROGENIC ACID | Inhibition | - | % | - |