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Assay Detail

CHEMBL2148748

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Cytotoxicity against human HCT116 assessed as decrease in cell count after 120 hrs
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type HCT-116
Confidence 1 — Organism
Curated By Autocuration

Target

HCT-116 (CHEMBL394)
Type CELL-LINE
Organism Homo sapiens

Publication

Synthesis and biological evaluation of a new vitamin D2 analogue.
Gándara Z, Pérez M, Salomón DG, Ferronato MJ, Fermento ME, Curino AC, Facchinetti MM, Gómez G, Fall Y.
Bioorg Med Chem Lett (2012) 22 : 6276 -6279
PubMed 22926068 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 2 10.06 11.00

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL846 CALCITRIOL 4.0 1 11.00
CHEMBL2146926 1 9.12

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL846 CALCITRIOL IC50 = 0.01 nM 11.00
CHEMBL2146926 IC50 = 0.76 nM 9.12