Assay Detail
Binding
CHEMBL2149374
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human recombinant LMW-PTP2 expressed in Escherichia coli TB1 using p-nitrophenyl phosphate as substrate after 1 hr
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Low molecular weight phosphotyrosine protein phosphatase (CHEMBL4903) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Antidiabetic activity of some pentacyclic acid triterpenoids, role of PTP-1B: in vitro, in silico, and in vivo approaches.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 4.67 | 4.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL169 | URSOLIC ACID | 2.0 | 1 | 4.96 |
| CHEMBL168 | OLEANOLIC_ACID | — | 1 | 4.64 |
| CHEMBL472646 | MORONIC ACID | — | 1 | 4.56 |
| CHEMBL463665 | MOROLIC ACID | — | 1 | 4.51 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL169 | URSOLIC ACID | IC50 | = | 11100.0 | nM | 4.96 |
| CHEMBL168 | OLEANOLIC_ACID | IC50 | = | 22900.0 | nM | 4.64 |
| CHEMBL472646 | MORONIC ACID | IC50 | = | 27400.0 | nM | 4.56 |
| CHEMBL463665 | MOROLIC ACID | IC50 | = | 30600.0 | nM | 4.51 |