Assay Detail
Binding
CHEMBL2149377
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Mixed type inhibition of human recombinant PTP-1B expressed in Escherichia coli TB1 using p-nitrophenyl phosphate as substrate
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Tyrosine-protein phosphatase non-receptor type 1 (CHEMBL335) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Antidiabetic activity of some pentacyclic acid triterpenoids, role of PTP-1B: in vitro, in silico, and in vivo approaches.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 3 | 5.26 | 5.47 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL169 | URSOLIC ACID | 2.0 | 1 | 5.47 |
| CHEMBL168 | OLEANOLIC_ACID | — | 1 | 5.22 |
| CHEMBL472646 | MORONIC ACID | — | 1 | 5.10 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL169 | URSOLIC ACID | Ki | = | 3400.0 | nM | 5.47 |
| CHEMBL168 | OLEANOLIC_ACID | Ki | = | 6000.0 | nM | 5.22 |
| CHEMBL472646 | MORONIC ACID | Ki | = | 8000.0 | nM | 5.10 |