Assay Detail
Functional
CHEMBL2149665
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Cytotoxicity against human HL60 cells after 72 hrs by MTT assay
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HL-60 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Newly synthesized bis-benzimidazole derivatives exerting anti-tumor activity through induction of apoptosis and autophagy.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 5.54 | 8.55 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL428647 | PACLITAXEL | 4.0 | 1 | 8.55 |
| CHEMBL185 | FLUOROURACIL | 4.0 | 1 | 7.22 |
| CHEMBL2147620 | — | — | 1 | 6.25 |
| CHEMBL2147621 | — | — | 1 | 5.20 |
| CHEMBL2147622 | — | — | 1 | 5.12 |
| CHEMBL2147623 | — | — | 1 | 5.09 |
| CHEMBL2147626 | — | — | 1 | 4.80 |
| CHEMBL2147624 | — | — | 1 | 4.78 |
| CHEMBL2147625 | — | — | 1 | 4.76 |
| CHEMBL2147627 | — | — | 1 | 4.63 |
| CHEMBL301735 | HOECHST 33258 | — | 1 | 4.49 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL428647 | PACLITAXEL | IC50 | = | 2.82 | nM | 8.55 |
| CHEMBL185 | FLUOROURACIL | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL2147620 | — | IC50 | = | 560.0 | nM | 6.25 |
| CHEMBL2147621 | — | IC50 | = | 6350.0 | nM | 5.20 |
| CHEMBL2147622 | — | IC50 | = | 7560.0 | nM | 5.12 |
| CHEMBL2147623 | — | IC50 | = | 8170.0 | nM | 5.09 |
| CHEMBL2147626 | — | IC50 | = | 15780.0 | nM | 4.80 |
| CHEMBL2147624 | — | IC50 | = | 16470.0 | nM | 4.78 |
| CHEMBL2147625 | — | IC50 | = | 17220.0 | nM | 4.76 |
| CHEMBL2147627 | — | IC50 | = | 23190.0 | nM | 4.63 |
| CHEMBL301735 | HOECHST 33258 | IC50 | = | 32430.0 | nM | 4.49 |