Assay Detail
Binding
CHEMBL2149805
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human DPP9 using GLY-Pro-MCA as substrate after 30 mins by cell-based fluorescence assay
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery and preclinical profile of teneligliptin (3-[(2S,4S)-4-[4-(3-methyl-1-phenyl-1H-pyrazol-5-yl)piperazin-1-yl]pyrrolidin-2-ylcarbonyl]thiazolidine): a highly potent, selective, long-lasting and orally active dipeptidyl peptidase IV inhibitor for the treatment of type 2 diabetes.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 6.69 | 7.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL391466 | — | — | 1 | 7.52 |
| CHEMBL241253 | — | — | 1 | 6.96 |
| CHEMBL2147712 | — | — | 1 | 6.48 |
| CHEMBL2147777 | TENELIGLIPTIN | 4.0 | 1 | 6.27 |
| CHEMBL2147771 | — | — | 1 | 6.21 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL391466 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL241253 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL2147712 | — | IC50 | = | 330.0 | nM | 6.48 |
| CHEMBL2147777 | TENELIGLIPTIN | IC50 | = | 540.0 | nM | 6.27 |
| CHEMBL2147771 | — | IC50 | = | 610.0 | nM | 6.21 |