Assay Detail
Binding
CHEMBL2149839
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Inhibition of mushroom tyrosinase using as L-DOPA substrate after 2 mins by spectrophotometric analysis
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Agaricus bisporus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Tyrosinase inhibitory activity of a 6-isoprenoid-substituted flavanone isolated from Dalea elegans.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 4.58 | 4.73 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2147165 | DALENIN | — | 1 | 4.73 |
| CHEMBL287556 | KOJIC ACID | — | 1 | 4.73 |
| CHEMBL465194 | STEPPOGENIN | — | 1 | 4.58 |
| CHEMBL2147166 | — | — | 1 | 4.29 |
| CHEMBL537 | HYDROQUINONE | 4.0 | 1 | - |
| CHEMBL232202 | ARBUTIN | 2.0 | 1 | - |
| CHEMBL196 | ASCORBIC ACID | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2147165 | DALENIN | IC50 | = | 18610.0 | nM | 4.73 |
| CHEMBL287556 | KOJIC ACID | IC50 | = | 18570.0 | nM | 4.73 |
| CHEMBL465194 | STEPPOGENIN | IC50 | = | 26500.0 | nM | 4.58 |
| CHEMBL2147166 | — | IC50 | = | 51870.0 | nM | 4.29 |
| CHEMBL537 | HYDROQUINONE | IC50 | = | 1090560.0 | nM | - |
| CHEMBL232202 | ARBUTIN | IC50 | = | 5300000.0 | nM | - |
| CHEMBL196 | ASCORBIC ACID | IC50 | = | 140000.0 | nM | - |