Assay Detail
Functional
CHEMBL2150100
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Cytotoxicity against human HL60 cells assessed as cell viability after 48 hrs by celltiter-blue assay
54
Total Activities
54
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HL-60 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Structure-activity relationship (SAR) study of ethyl 2-amino-6-(3,5-dimethoxyphenyl)-4-(2-ethoxy-2-oxoethyl)-4H-chromene-3-carboxylate (CXL017) and the potential of the lead against multidrug resistance in cancer treatment.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 54 | 5.35 | 8.15 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL96926 | THAPSIGARGIN | — | 1 | 8.15 |
| CHEMBL58 | MITOXANTRONE | 4.0 | 1 | 7.80 |
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | 7.40 |
| CHEMBL803 | CYTARABINE | 4.0 | 1 | 7.31 |
| CHEMBL90555 | VINCRISTINE | 4.0 | 1 | 7.22 |
| CHEMBL44657 | ETOPOSIDE | 4.0 | 1 | 6.96 |
| CHEMBL2147958 | — | — | 1 | 6.21 |
| CHEMBL2147954 | — | — | 1 | 6.20 |
| CHEMBL376408 | ABT 737 | 1.0 | 1 | 6.12 |
| CHEMBL2147961 | — | — | 1 | 6.06 |
| CHEMBL2147890 | — | — | 1 | 5.91 |
| CHEMBL1819010 | — | — | 1 | 5.82 |
| CHEMBL2147967 | — | — | 1 | 5.79 |
| CHEMBL2147964 | — | — | 1 | 5.73 |
| CHEMBL2147871 | — | — | 1 | 5.62 |
| CHEMBL2147968 | — | — | 1 | 5.61 |
| CHEMBL2147969 | — | — | 1 | 5.59 |
| CHEMBL2147889 | — | — | 1 | 5.47 |
| CHEMBL1819011 | — | — | 1 | 5.33 |
| CHEMBL1819009 | — | — | 1 | 5.33 |
| CHEMBL2147965 | — | — | 1 | 5.28 |
| CHEMBL2147966 | — | — | 1 | 5.27 |
| CHEMBL1915706 | — | — | 1 | 5.17 |
| CHEMBL1819012 | — | — | 1 | 5.17 |
| CHEMBL2147960 | — | — | 1 | 5.15 |
| CHEMBL2147971 | — | — | 1 | 5.14 |
| CHEMBL2147959 | — | — | 1 | 5.13 |
| CHEMBL1818900 | — | — | 1 | 5.12 |
| CHEMBL2147885 | — | — | 1 | 4.99 |
| CHEMBL2147887 | — | — | 1 | 4.99 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL96926 | THAPSIGARGIN | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL58 | MITOXANTRONE | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL53463 | DOXORUBICIN | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL803 | CYTARABINE | IC50 | = | 49.0 | nM | 7.31 |
| CHEMBL90555 | VINCRISTINE | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL44657 | ETOPOSIDE | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL2147958 | — | IC50 | = | 610.0 | nM | 6.21 |
| CHEMBL2147954 | — | IC50 | = | 630.0 | nM | 6.20 |
| CHEMBL376408 | ABT 737 | IC50 | = | 760.0 | nM | 6.12 |
| CHEMBL2147961 | — | IC50 | = | 880.0 | nM | 6.06 |
| CHEMBL2147890 | — | IC50 | = | 1240.0 | nM | 5.91 |
| CHEMBL1819010 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL2147967 | — | IC50 | = | 1620.0 | nM | 5.79 |
| CHEMBL2147964 | — | IC50 | = | 1860.0 | nM | 5.73 |
| CHEMBL2147871 | — | IC50 | = | 2420.0 | nM | 5.62 |
| CHEMBL2147968 | — | IC50 | = | 2450.0 | nM | 5.61 |
| CHEMBL2147969 | — | IC50 | = | 2560.0 | nM | 5.59 |
| CHEMBL2147889 | — | IC50 | = | 3400.0 | nM | 5.47 |
| CHEMBL1819011 | — | IC50 | = | 4700.0 | nM | 5.33 |
| CHEMBL1819009 | — | IC50 | = | 4700.0 | nM | 5.33 |
| CHEMBL2147965 | — | IC50 | = | 5300.0 | nM | 5.28 |
| CHEMBL2147966 | — | IC50 | = | 5400.0 | nM | 5.27 |
| CHEMBL1915706 | — | IC50 | = | 6800.0 | nM | 5.17 |
| CHEMBL1819012 | — | IC50 | = | 6700.0 | nM | 5.17 |
| CHEMBL2147960 | — | IC50 | = | 7130.0 | nM | 5.15 |
| CHEMBL2147971 | — | IC50 | = | 7270.0 | nM | 5.14 |
| CHEMBL2147959 | — | IC50 | = | 7450.0 | nM | 5.13 |
| CHEMBL1818900 | — | IC50 | = | 7600.0 | nM | 5.12 |
| CHEMBL2147885 | — | IC50 | = | 10200.0 | nM | 4.99 |
| CHEMBL2147887 | — | IC50 | = | 10200.0 | nM | 4.99 |
| CHEMBL2147957 | — | IC50 | = | 10500.0 | nM | 4.98 |
| CHEMBL2147872 | — | IC50 | = | 10800.0 | nM | 4.97 |
| CHEMBL561602 | — | IC50 | = | 10700.0 | nM | 4.97 |
| CHEMBL2147962 | — | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL2147963 | — | IC50 | = | 17200.0 | nM | 4.76 |
| CHEMBL2147874 | — | IC50 | = | 19600.0 | nM | 4.71 |
| CHEMBL2147888 | — | IC50 | = | 20200.0 | nM | 4.70 |
| CHEMBL2147884 | — | IC50 | = | 21500.0 | nM | 4.67 |
| CHEMBL2147956 | — | IC50 | = | 22300.0 | nM | 4.65 |
| CHEMBL1819008 | — | IC50 | = | 32000.0 | nM | 4.50 |
| CHEMBL2147970 | — | IC50 | = | 33000.0 | nM | 4.48 |
| CHEMBL2147880 | — | IC50 | = | 35900.0 | nM | 4.45 |
| CHEMBL2147886 | — | IC50 | = | 37900.0 | nM | 4.42 |
| CHEMBL2147955 | — | IC50 | = | 43900.0 | nM | 4.36 |
| CHEMBL2147878 | — | IC50 | = | 72100.0 | nM | 4.14 |
| CHEMBL2147876 | — | IC50 | = | 73000.0 | nM | 4.14 |
| CHEMBL2147879 | — | IC50 | = | 76600.0 | nM | 4.12 |
| CHEMBL2147877 | — | IC50 | = | 76400.0 | nM | 4.12 |
| CHEMBL2147883 | — | IC50 | = | 76900.0 | nM | 4.11 |
| CHEMBL560141 | — | IC50 | = | 91000.0 | nM | 4.04 |