Assay Detail
Functional
CHEMBL2150102
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Cytotoxicity against human CCRF-CEM cells assessed as cell viability after 48 hrs by celltiter-blue assay
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | CCRF-CEM |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Structure-activity relationship (SAR) study of ethyl 2-amino-6-(3,5-dimethoxyphenyl)-4-(2-ethoxy-2-oxoethyl)-4H-chromene-3-carboxylate (CXL017) and the potential of the lead against multidrug resistance in cancer treatment.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 6.97 | 9.77 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL90555 | VINCRISTINE | 4.0 | 1 | 9.77 |
| CHEMBL803 | CYTARABINE | 4.0 | 1 | 8.22 |
| CHEMBL58 | MITOXANTRONE | 4.0 | 1 | 7.44 |
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | 6.96 |
| CHEMBL44657 | ETOPOSIDE | 4.0 | 1 | 6.62 |
| CHEMBL96926 | THAPSIGARGIN | — | 1 | 6.57 |
| CHEMBL376408 | ABT 737 | 1.0 | 1 | 6.13 |
| CHEMBL2147958 | — | — | 1 | 5.83 |
| CHEMBL1915706 | — | — | 1 | 5.15 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL90555 | VINCRISTINE | IC50 | = | 0.17 | nM | 9.77 |
| CHEMBL803 | CYTARABINE | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL58 | MITOXANTRONE | IC50 | = | 36.0 | nM | 7.44 |
| CHEMBL53463 | DOXORUBICIN | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL44657 | ETOPOSIDE | IC50 | = | 240.0 | nM | 6.62 |
| CHEMBL96926 | THAPSIGARGIN | IC50 | = | 270.0 | nM | 6.57 |
| CHEMBL376408 | ABT 737 | IC50 | = | 740.0 | nM | 6.13 |
| CHEMBL2147958 | — | IC50 | = | 1470.0 | nM | 5.83 |
| CHEMBL1915706 | — | IC50 | = | 7050.0 | nM | 5.15 |