Assay Detail
Functional
CHEMBL2150722
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antagonist activity at Pseudomonas aeruginosa LasB using Abz-Ala-Gly-Leu-Ala-p-Nitro-Benzyl-Amide as substrate incubated for 30 mins prior to substrate addition by FRET assay
19
Total Activities
13
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Pseudomonas aeruginosa |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Elastase (CHEMBL1075146) ↗| Type | SINGLE PROTEIN |
| Organism | Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG12228) |
Publication
3-Hydroxy-1-alkyl-2-methylpyridine-4(1H)-thiones: Inhibition of the Pseudomonas aeruginosa Virulence Factor LasB.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 5.01 | 5.56 |
| Activity | 6 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2146996 | — | — | 1 | 5.56 |
| CHEMBL2146995 | — | — | 1 | 5.48 |
| CHEMBL2146997 | — | — | 1 | 5.45 |
| CHEMBL2146998 | — | — | 1 | 5.33 |
| CHEMBL2147001 | — | — | 1 | 5.28 |
| CHEMBL2146999 | — | — | 1 | 5.17 |
| CHEMBL2147000 | — | — | 1 | 5.07 |
| CHEMBL152665 | PHENYLACETOHYDROXAMIC ACID | — | 2 | 4.87 |
| CHEMBL2146994 | — | — | 2 | 4.79 |
| CHEMBL1650620 | — | — | 2 | 4.09 |
| CHEMBL1650624 | — | — | 2 | 4.05 |
| CHEMBL1650623 | — | — | 2 | - |
| CHEMBL1650621 | — | — | 2 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2146996 | — | IC50 | = | 2730.0 | nM | 5.56 |
| CHEMBL2146995 | — | IC50 | = | 3340.0 | nM | 5.48 |
| CHEMBL2146997 | — | IC50 | = | 3580.0 | nM | 5.45 |
| CHEMBL2146998 | — | IC50 | = | 4650.0 | nM | 5.33 |
| CHEMBL2147001 | — | IC50 | = | 5270.0 | nM | 5.28 |
| CHEMBL2146999 | — | IC50 | = | 6720.0 | nM | 5.17 |
| CHEMBL2147000 | — | IC50 | = | 8580.0 | nM | 5.07 |
| CHEMBL152665 | PHENYLACETOHYDROXAMIC ACID | IC50 | = | 13600.0 | nM | 4.87 |
| CHEMBL2146994 | — | IC50 | = | 16400.0 | nM | 4.79 |
| CHEMBL1650620 | — | IC50 | = | 80600.0 | nM | 4.09 |
| CHEMBL1650624 | — | IC50 | = | 88500.0 | nM | 4.05 |
| CHEMBL1650621 | — | IC50 | = | 220000.0 | nM | - |
| CHEMBL1650623 | — | IC50 | = | 392000.0 | nM | - |
| CHEMBL152665 | PHENYLACETOHYDROXAMIC ACID | Activity | - | — | - | |
| CHEMBL2146994 | — | Activity | - | — | - | |
| CHEMBL1650620 | — | Activity | - | — | - | |
| CHEMBL1650624 | — | Activity | - | — | - | |
| CHEMBL1650623 | — | Activity | - | — | - | |
| CHEMBL1650621 | — | Activity | - | — | - |