Assay Detail
Binding
CHEMBL2153950
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Displacement of [125I]-Tyr6, His5 from human LHRH1 receptor expressed in HEK 293 cells after 16 to 19 hrs by gamma counter
13
Total Activities
7
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Rationally designed cyclic analogues of luteinizing hormone-releasing hormone: enhanced enzymatic stability and biological properties.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Inhibition | 7 | - | - |
| IC50 | 6 | 6.26 | 9.12 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1201199 | LEUPROLIDE | 4.0 | 2 | 9.12 |
| CHEMBL2370110 | — | — | 2 | 6.17 |
| CHEMBL2370111 | — | — | 2 | 5.82 |
| CHEMBL2370114 | — | — | 2 | 5.58 |
| CHEMBL2370113 | — | — | 2 | 5.54 |
| CHEMBL2370112 | — | — | 2 | 5.31 |
| CHEMBL1007 | GONADORELIN | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1201199 | LEUPROLIDE | IC50 | = | 0.7586 | nM | 9.12 |
| CHEMBL2370110 | — | IC50 | = | 676.08 | nM | 6.17 |
| CHEMBL2370111 | — | IC50 | = | 1513.56 | nM | 5.82 |
| CHEMBL2370114 | — | IC50 | = | 2630.27 | nM | 5.58 |
| CHEMBL2370113 | — | IC50 | = | 2884.03 | nM | 5.54 |
| CHEMBL2370112 | — | IC50 | = | 4897.79 | nM | 5.31 |
| CHEMBL1007 | GONADORELIN | Inhibition | - | % | - | |
| CHEMBL1201199 | LEUPROLIDE | Inhibition | - | % | - | |
| CHEMBL2370110 | — | Inhibition | - | % | - | |
| CHEMBL2370111 | — | Inhibition | - | % | - | |
| CHEMBL2370112 | — | Inhibition | - | % | - | |
| CHEMBL2370113 | — | Inhibition | - | % | - | |
| CHEMBL2370114 | — | Inhibition | - | % | - |