Assay Detail
Binding
CHEMBL2154079
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of COX2-mediated PGE2 production in LPS-induced mouse J774 cells by radioimmunoassay
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mus musculus |
| Cell Type | J774 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Improving the solubility of a new class of antiinflammatory pharmacodynamic hybrids, that release nitric oxide and inhibit cycloxygenase-2 isoenzyme.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 6.04 | 6.66 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2153831 | — | — | 1 | 6.66 |
| CHEMBL2153829 | — | — | 1 | 6.12 |
| CHEMBL2153825 | — | — | 1 | 6.09 |
| CHEMBL2153827 | — | — | 1 | 6.00 |
| CHEMBL2153830 | — | — | 1 | 5.92 |
| CHEMBL2153828 | — | — | 1 | 5.85 |
| CHEMBL2153826 | — | — | 1 | 5.82 |
| CHEMBL2153832 | — | — | 1 | 5.82 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2153831 | — | IC50 | = | 220.0 | nM | 6.66 |
| CHEMBL2153829 | — | IC50 | = | 760.0 | nM | 6.12 |
| CHEMBL2153825 | — | IC50 | = | 820.0 | nM | 6.09 |
| CHEMBL2153827 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL2153830 | — | IC50 | = | 1190.0 | nM | 5.92 |
| CHEMBL2153828 | — | IC50 | = | 1410.0 | nM | 5.85 |
| CHEMBL2153826 | — | IC50 | = | 1510.0 | nM | 5.82 |
| CHEMBL2153832 | — | IC50 | = | 1500.0 | nM | 5.82 |