Assay Detail
Functional
CHEMBL2154107
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Vasorelaxant activity in Wistar rat endothelium-denuded thoracic aortic ring assessed as inhibition of KCl-induced contractile tone in presence of guanylate cyclase inhibitor ODQ
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Tissue | Aorta |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Improving the solubility of a new class of antiinflammatory pharmacodynamic hybrids, that release nitric oxide and inhibit cycloxygenase-2 isoenzyme.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 5.98 | 6.48 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1939670 | — | — | 1 | 6.48 |
| CHEMBL2153827 | — | — | 1 | 5.81 |
| CHEMBL2153825 | — | — | 1 | 5.66 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1939670 | — | IC50 | = | 331.13 | nM | 6.48 |
| CHEMBL2153827 | — | IC50 | = | 1548.82 | nM | 5.81 |
| CHEMBL2153825 | — | IC50 | = | 2187.76 | nM | 5.66 |