Assay Detail
Binding
CHEMBL2154121
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Inhibition of human OCT2 A270S mutant expressed in HEK-293-Flp-In cells incubated for 3 mins by ASP+ substrate uptake assay
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Profiling of a prescription drug library for potential renal drug-drug interactions mediated by the organic cation transporter 2.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 5.44 | 5.92 |
Compounds Tested
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL95 | TACRINE | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL11 | IMIPRAMINE | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL46 | ONDANSETRON | IC50 | = | 2800.0 | nM | 5.55 |
| CHEMBL932 | DIPYRIDAMOLE | IC50 | = | 3800.0 | nM | 5.42 |
| CHEMBL517 | DISOPYRAMIDE | IC50 | = | 3900.0 | nM | 5.41 |
| CHEMBL900 | ORPHENADRINE | IC50 | = | 4300.0 | nM | 5.37 |
| CHEMBL30 | CIMETIDINE | IC50 | = | 20000.0 | nM | 4.70 |