Assay Detail
Functional
CHEMBL2155123
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Agonist activity at GPR40 expressed in CHO cells after 20 seconds by aequorin bioluminescence assay in presence of 0.1 % human serum
23
Total Activities
23
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of AM-1638: A Potent and Orally Bioavailable GPR40/FFA1 Full Agonist.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 23 | 5.93 | 7.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1829173 | — | — | 1 | 7.22 |
| CHEMBL2152070 | — | — | 1 | 6.80 |
| CHEMBL2151298 | — | — | 1 | 6.43 |
| CHEMBL2151299 | — | — | 1 | 6.38 |
| CHEMBL2152069 | — | — | 1 | 6.32 |
| CHEMBL2151288 | — | — | 1 | 6.19 |
| CHEMBL2151295 | — | — | 1 | 6.17 |
| CHEMBL2151296 | — | — | 1 | 6.16 |
| CHEMBL2151294 | — | — | 1 | 6.11 |
| CHEMBL2151293 | — | — | 1 | 6.05 |
| CHEMBL2152071 | — | — | 1 | 5.96 |
| CHEMBL2151292 | — | — | 1 | 5.92 |
| CHEMBL2151302 | — | — | 1 | 5.92 |
| CHEMBL2151300 | — | — | 1 | 5.88 |
| CHEMBL2151291 | — | — | 1 | 5.72 |
| CHEMBL2151301 | — | — | 1 | 5.68 |
| CHEMBL2152068 | — | — | 1 | 5.68 |
| CHEMBL2151297 | — | — | 1 | 5.66 |
| CHEMBL2151290 | — | — | 1 | 5.64 |
| CHEMBL2151287 | — | — | 1 | 5.64 |
| CHEMBL2151289 | — | — | 1 | 5.40 |
| CHEMBL1939651 | — | — | 1 | 5.11 |
| CHEMBL367149 | DOCONEXENT | 3.0 | 1 | 4.44 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1829173 | — | EC50 | = | 60.0 | nM | 7.22 |
| CHEMBL2152070 | — | EC50 | = | 160.0 | nM | 6.80 |
| CHEMBL2151298 | — | EC50 | = | 370.0 | nM | 6.43 |
| CHEMBL2151299 | — | EC50 | = | 420.0 | nM | 6.38 |
| CHEMBL2152069 | — | EC50 | = | 480.0 | nM | 6.32 |
| CHEMBL2151288 | — | EC50 | = | 650.0 | nM | 6.19 |
| CHEMBL2151295 | — | EC50 | = | 680.0 | nM | 6.17 |
| CHEMBL2151296 | — | EC50 | = | 690.0 | nM | 6.16 |
| CHEMBL2151294 | — | EC50 | = | 770.0 | nM | 6.11 |
| CHEMBL2151293 | — | EC50 | = | 900.0 | nM | 6.05 |
| CHEMBL2152071 | — | EC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL2151292 | — | EC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL2151302 | — | EC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL2151300 | — | EC50 | = | 1310.0 | nM | 5.88 |
| CHEMBL2151291 | — | EC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL2151301 | — | EC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL2152068 | — | EC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL2151297 | — | EC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL2151290 | — | EC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL2151287 | — | EC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL2151289 | — | EC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL1939651 | — | EC50 | = | 7700.0 | nM | 5.11 |
| CHEMBL367149 | DOCONEXENT | EC50 | = | 36000.0 | nM | 4.44 |