Compound Detail
CHEMBL2151289
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Basic Information
| ChEMBL ID | CHEMBL2151289 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | GPGWSJNBTROZBS-JOCHJYFZSA-N |
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
400.5
MW (Da)
5.52
ALogP
3
HBA
1
HBD
55.8
PSA (Ų)
0.51
QED
1
Ro5 Violations
8
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
EC50 2 meas. best 7.03
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| GPR40-Galpha16 CHEMBL5482994 | EC50 | 7.03 | 7.03 | 93.3 | 1 |
| Free fatty acid receptor 1 CHEMBL4422 | EC50 | 5.4 | 5.4 | 4000.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| GPR40-Galpha16 | EC50 | = | 93.3 | nM | 7.03 | Agonist activity at human GPR40/Galpha-16 expressed in HEK293 cells by Fluo4-AM ... | 36933395 |
| Free fatty acid receptor 1 | EC50 | = | 4000.0 | nM | 5.4 | Agonist activity at GPR40 expressed in CHO cells after 20 seconds by aequorin bi... | 24900539 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 24900539 | 10.1021/ml300133f | Free fatty acid receptor 1 | 2 |
| 36933395 | 10.1016/j.ejmech.2023.115267 | GPR40-Galpha16 | 2 |
Data from ChEMBL 36 via Core Engine