Assay Detail
Binding
CHEMBL2155141
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Inhibition of human JNK2alpha2 using GST-c-jun (1 to 221) as substrate preincubated for 30 mins before [gamma-32P]-ATP addition measured after 10 mins by liquid scintillation counting
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
From in Silico Discovery to intra-Cellular Activity: Targeting JNK-Protein Interactions with Small Molecules.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 5.19 | 6.20 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1969923 | — | — | 1 | 6.20 |
| CHEMBL1981814 | — | — | 1 | 5.66 |
| CHEMBL1980140 | — | — | 1 | 5.60 |
| CHEMBL2151191 | — | — | 1 | 5.60 |
| CHEMBL1492532 | — | — | 1 | 5.11 |
| CHEMBL2000337 | — | — | 1 | 4.97 |
| CHEMBL1189513 | FURALTADONE | 2.0 | 1 | 4.87 |
| CHEMBL2151192 | — | — | 1 | 4.85 |
| CHEMBL2151286 | — | — | 1 | 4.81 |
| CHEMBL2151285 | — | — | 1 | 4.70 |
| CHEMBL2151193 | — | — | 1 | 4.67 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1969923 | — | IC50 | = | 630.0 | nM | 6.20 |
| CHEMBL1981814 | — | IC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL1980140 | — | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL2151191 | — | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL1492532 | — | IC50 | = | 7700.0 | nM | 5.11 |
| CHEMBL2000337 | — | IC50 | = | 10700.0 | nM | 4.97 |
| CHEMBL1189513 | FURALTADONE | IC50 | = | 13500.0 | nM | 4.87 |
| CHEMBL2151192 | — | IC50 | = | 14000.0 | nM | 4.85 |
| CHEMBL2151286 | — | IC50 | = | 15500.0 | nM | 4.81 |
| CHEMBL2151285 | — | IC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL2151193 | — | IC50 | = | 21500.0 | nM | 4.67 |