Assay Detail
Binding
CHEMBL2155143
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of FITC-JIP peptide from human His-tagged JNK2alpha2 after 30 mins by fluorescence assay
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
From in Silico Discovery to intra-Cellular Activity: Targeting JNK-Protein Interactions with Small Molecules.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 5.01 | 5.77 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1969923 | — | — | 1 | 5.77 |
| CHEMBL2151191 | — | — | 1 | 5.66 |
| CHEMBL1981814 | — | — | 1 | 5.66 |
| CHEMBL2151286 | — | — | 1 | 5.11 |
| CHEMBL2151285 | — | — | 1 | 4.84 |
| CHEMBL2151193 | — | — | 1 | 4.39 |
| CHEMBL2000337 | — | — | 1 | 4.37 |
| CHEMBL2151192 | — | — | 1 | 4.24 |
| CHEMBL2151190 | — | — | 1 | - |
| CHEMBL1980140 | — | — | 1 | - |
| CHEMBL1492532 | — | — | 1 | - |
| CHEMBL1189513 | FURALTADONE | 2.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1969923 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL2151191 | — | IC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL1981814 | — | IC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL2151286 | — | IC50 | = | 7800.0 | nM | 5.11 |
| CHEMBL2151285 | — | IC50 | = | 14500.0 | nM | 4.84 |
| CHEMBL2151193 | — | IC50 | = | 41000.0 | nM | 4.39 |
| CHEMBL2000337 | — | IC50 | = | 43000.0 | nM | 4.37 |
| CHEMBL2151192 | — | IC50 | = | 58000.0 | nM | 4.24 |
| CHEMBL2151190 | — | IC50 | - | — | - | |
| CHEMBL1980140 | — | IC50 | - | — | - | |
| CHEMBL1492532 | — | IC50 | - | — | - | |
| CHEMBL1189513 | FURALTADONE | IC50 | - | — | - |