Assay Detail
Binding
CHEMBL2155306
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Inhibition of human F10a using S-2765 as substrate after 45 mins
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis and structure-activity relationship of potent, selective and orally active anthranilamide-based factor Xa inhibitors: application of weakly basic sulfoximine group as novel S4 binding element.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 8.39 | 8.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL198362 | RIVAROXABAN | 4.0 | 1 | 8.80 |
| CHEMBL3392119 | — | — | 1 | 8.68 |
| CHEMBL3392130 | — | — | 1 | 8.62 |
| CHEMBL3392115 | — | — | 1 | 8.57 |
| CHEMBL3392121 | — | — | 1 | 8.49 |
| CHEMBL3392131 | — | — | 1 | 8.47 |
| CHEMBL3392116 | — | — | 1 | 8.40 |
| CHEMBL3392114 | — | — | 1 | 8.27 |
| CHEMBL3392129 | — | — | 1 | 8.25 |
| CHEMBL3392132 | — | — | 1 | 8.19 |
| CHEMBL3392118 | — | — | 1 | 8.05 |
| CHEMBL3392133 | — | — | 1 | 7.94 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL198362 | RIVAROXABAN | IC50 | = | 1.6 | nM | 8.80 |
| CHEMBL3392119 | — | IC50 | = | 2.1 | nM | 8.68 |
| CHEMBL3392130 | — | IC50 | = | 2.4 | nM | 8.62 |
| CHEMBL3392115 | — | IC50 | = | 2.7 | nM | 8.57 |
| CHEMBL3392121 | — | IC50 | = | 3.2 | nM | 8.49 |
| CHEMBL3392131 | — | IC50 | = | 3.4 | nM | 8.47 |
| CHEMBL3392116 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL3392114 | — | IC50 | = | 5.4 | nM | 8.27 |
| CHEMBL3392129 | — | IC50 | = | 5.6 | nM | 8.25 |
| CHEMBL3392132 | — | IC50 | = | 6.4 | nM | 8.19 |
| CHEMBL3392118 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL3392133 | — | IC50 | = | 11.6 | nM | 7.94 |